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DEFA6(?-100) [extracellular region]
Stable Identifier
R-HSA-1462032
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Defensin alpha 6, Defensin-6, DEF6_HUMAN, DEFA6
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Defensins (Homo sapiens)
Alpha-defensins (Homo sapiens)
Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin-6 dimer [extracellular region] (Homo sapiens)
DEFA6(?-100) [extracellular region] (Homo sapiens)
Alpha-defensin dimers:anionic phospholipids [plasma membrane] (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin-6 dimer [extracellular region] (Homo sapiens)
DEFA6(?-100) [extracellular region] (Homo sapiens)
Alpha-defensin dimers multimerize to form a pore complex (Homo sapiens)
Alpha-defensin dimers:anionic phospholipids [plasma membrane] (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin-6 dimer [extracellular region] (Homo sapiens)
DEFA6(?-100) [extracellular region] (Homo sapiens)
Alpha-defensin pore complex [plasma membrane] (Homo sapiens)
Alpha-defensin dimers:anionic phospholipids [plasma membrane] (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin-6 dimer [extracellular region] (Homo sapiens)
DEFA6(?-100) [extracellular region] (Homo sapiens)
Alpha-defensins form biologically active dimers (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin-6 dimer [extracellular region] (Homo sapiens)
DEFA6(?-100) [extracellular region] (Homo sapiens)
Alpha-defensins [extracellular region] (Homo sapiens)
DEFA6(?-100) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01524 DEFA6
Gene Names
DEFA6, DEF6
Chain
signal peptide:1-19, propeptide:20-68, peptide:69-100
Reference Genes
BioGPS Gene:1671 DEFA6
COSMIC (genes):DEF6 DEFA6
COSMIC (genes):DEFA6 DEFA6
CTD Gene:1671 DEFA6
dbSNP Gene:1671 DEFA6
ENSEMBL:ENSG00000164822 DEFA6
HGNC:2765 DEFA6
KEGG:hsa:1671 DEFA6
Monarch:1671 DEFA6
NCBI Gene:1671 DEFA6
OMIM:600471 DEFA6
UCSC:Q01524 DEFA6
Reference Transcript
RefSeq:NM_001926.3 DEFA6
Other Identifiers
11732988_at
1671
17074301
207814_PM_at
207814_at
3122714
3122715
3122716
3122717
3122718
34622_at
8149104
A_23_P82886
A_24_P363711
GE525001
GO:0002227
GO:0002376
GO:0005515
GO:0005576
GO:0005615
GO:0005796
GO:0006952
GO:0019731
GO:0030133
GO:0031410
GO:0031640
GO:0042742
GO:0042803
GO:0043226
GO:0045087
GO:0050829
GO:0050830
GO:0050832
GO:0051673
GO:0061844
GO:0071222
GO:0098542
HMNXSV003035232
ILMN_1759089
TC08000907.hg
U33317_rna1_at
g12621917_3p_at
Participates
as a member of
Alpha-defensins [extracellular region] (Homo sapiens)
as a component of
Defensin-6 dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
DEFA6(20-100) [Golgi lumen]
DEFA6(1-100) [Golgi lumen]
Inferred To
DEFA6(?-100) [extracellular region]
(Mus musculus)
DEFA6(?-100) [extracellular region]
(Rattus norvegicus)
Homologues of DEFA6(?-100) [extracellular region]
(Mus musculus)
Homologues of DEFA6(?-100) [extracellular region]
(Rattus norvegicus)
Defa35 [extracellular region]
(Mus musculus)
Defa28 [extracellular region]
(Mus musculus)
Defa31 [extracellular region]
(Mus musculus)
Defa31 [extracellular region]
(Rattus norvegicus)
Defa40 [extracellular region]
(Mus musculus)
Np4 [extracellular region]
(Rattus norvegicus)
Defa2 [extracellular region]
(Mus musculus)
Defa26 [extracellular region]
(Mus musculus)
Defa9 [extracellular region]
(Rattus norvegicus)
Defal1 [extracellular region]
(Rattus norvegicus)
Defa [extracellular region]
(Rattus norvegicus)
Defa23 [extracellular region]
(Mus musculus)
Defa39 [extracellular region]
(Mus musculus)
Defa42 [extracellular region]
(Mus musculus)
Defa21 [extracellular region]
(Mus musculus)
Defa25 [extracellular region]
(Mus musculus)
Defa29 [extracellular region]
(Mus musculus)
Defa34 [extracellular region]
(Mus musculus)
Defa8 [extracellular region]
(Rattus norvegicus)
Defa30 [extracellular region]
(Mus musculus)
Defa11 [extracellular region]
(Rattus norvegicus)
Defa3 [extracellular region]
(Mus musculus)
Defa6 [extracellular region]
(Rattus norvegicus)
ENSRNOG00000064390 [extracellular region]
(Rattus norvegicus)
Defa5 [extracellular region]
(Mus musculus)
Defa38 [extracellular region]
(Mus musculus)
Defa22 [extracellular region]
(Mus musculus)
Defa24 [extracellular region]
(Mus musculus)
Defa24 [extracellular region]
(Rattus norvegicus)
Defa17 [extracellular region]
(Mus musculus)
Defa41 [extracellular region]
(Mus musculus)
Defa20 [extracellular region]
(Mus musculus)
Defa36 [extracellular region]
(Mus musculus)
AY761185 [extracellular region]
(Mus musculus)
Cross References
RefSeq
NP_001917.1
ENSEMBL
ENSP00000494361
,
ENSP00000297436
,
ENST00000646187
,
ENST00000297436
OpenTargets
ENSG00000164822
HPA
ENSG00000164822-DEFA6
PRO
Q01524
Pharos - Targets
Q01524
PDB
3QTE
,
1ZMQ
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43909 EXTL3
1
EXTL3 [endoplasmic reticulum membrane]
(R-HSA-535476)
0.527
2
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