Corticosteroids bind to CBG in blood

Stable Identifier
R-HSA-1449687
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Corticosteroids are transported in blood bound to Transcortin
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Transcortin (corticosteroid-binding globulin, CBG, Serpin A6) (Hammond et al, 1987) is produced in the liver and functions as a plasma transporter of corticosteroids such as progesterone, aldosterone, cortisol and 11-deoxycorticosterone (Dunn et al, 1981). These hormones are biologically active when not bound to CBG therefore CBG may regulate the bioavailability of these hormones.

Literature References
PubMed ID Title Journal Year
3299377 Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors

Hammond, GL, Smith, CL, Goping, IS, Underhill, DA, Harley, MJ, Reventos, J, Musto, NA, Gunsalus, GL, Bardin, CW

Proc Natl Acad Sci U S A 1987
7195404 Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma

Dunn, JF, Nisula, BC, Rodbard, D

J Clin Endocrinol Metab 1981
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