Synthesis of PIP3 from PIP2 by PI3K

Stable Identifier
R-HSA-1433514
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PI3 kinases catalyze the production of phosphatidylinositol-3, 4, 5-triphosphate (PIP3) by phosphorylating phosphatidylinositol-4, 5-bisphosphate (PIP2). PIP3 bound to the inner lipid bilayer of the plasma membrane promotes the recruitment and activation of AKT. Active AKT subsequently phosphorylates the pro-apoptotic factor Bad at Ser136 which leads to it binding 14-3-3 protein and sequestering from the anti-apoptotic molecules Bcl-XL therby reducing antiapoptotic events and promoting cell survival. The alternative route for c-Kit mediated survival is through AKT-mediated phosphorylation and incativation of the forkhead transcription factor (FoxO3a) (Engstrom et al, 2003; Lennartson et al , 2005).

Literature References
PubMed ID Title Journal Year
12660731 The role of PI3K in immune cells

Koyasu, S

Nat Immunol 2003
11395417 Synthesis and function of 3-phosphorylated inositol lipids

Vanhaesebroeck, B, Leevers, SJ, Ahmadi, K, Timms, J, Katso, R, Driscoll, PC, Woscholski, R, Parker, PJ, Waterfield, MD

Annu Rev Biochem 2001
18697750 Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit

Sun, J, Pedersen, M, Rönnstrand, L

J Biol Chem 2008
Participants
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Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol 3-kinase activity of PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane]
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Orthologous Events
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