Phosphorylation of JAK2

Stable Identifier
Reaction [transition]
Homo sapiens
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SCF induces rapid and transient autophosphorylation of JAK2 bound to c-KIT. JAKs bound to activated, dimerized receptors cross-phosphorylate and thereby activate each other. Multiple phosphorylation sites have been identified in JAK2 (tyrosines 221, 570, 868, 966, 972, 1007 and 1008 ). Phosphorylation of tyrosine 1007 is essential for kinase activity (Feng et al 1997, Argetsinger et al. 2004, 2010). Tyrosine 1007 is in the activation loop and phosphorylation allows access of the catalytic loop to the ATP in the ATP binding domain. Of all the predicted phoshorylation sites only the critical tyrosine 1007 is represented in the reaction.
Literature References
PubMed ID Title Journal Year
9111318 Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

Matsuda, T, Witthuhn, BA, Kerr, IM, Kohlhuber, F, Feng, J, Ihle, JN

Mol Cell Biol 1997
15143187 Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity

Steen, H, Carter-Su, C, Argetsinger, LS, Jensen, ON, Kouadio, JL, Stensballe, A

Mol Cell Biol 2004
8611693 JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor

Keller, JR, Linnekin, D, Longo, DL, Mou, S, Ruscetti, FW, Ferris, DK, DeBerry, CS, Weiler, SR

Blood 1996
20304997 Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity

Carter-Su, C, Marto, JA, Cline, JM, Argetsinger, LS, Koleva, RI, Robertson, SA, Stuckey, JA, Myers MG, Jr

Mol Endocrinol 2010
Catalyst Activity

protein tyrosine kinase activity of JAK2:SFKS:p-KIT complex [plasma membrane]

Orthologous Events
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