Reactome | factor VII -> factor VIIa

factor VII -> factor VIIa

Stable Identifier

R-HSA-140769

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

activation of factor VII

ReviewStatus

5/5

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Coagulation factor VII (FVII) circulates in plasma mostly in the zymogen form (Morrissey JH et al. 1993). During the initiation stage of coagulation, activated factor Xa (FXa) catalyzes the proteolytic activation of FVII from plasma (Rao LV et al. 1986; reviewed by Nemerson Y 1988). As factor VIIa accumulates, the formed TF:FVIIa complex accelerates the process of FXa generation through a reciprocal activation of FXa and FVIIa toward each other. A frequent human FVII A354V variant affects both activation of FVII by FXa and activation of FX by FVIIa (Toso R et al., 2002; Fromovich-Amit Y et al., 2004).

This Reactome event shows cleavage of plasma zymogen FVII by soluble FXa between R212 and I213 in the region connecting the EGF2 and protease domains. This cleavage produces a two-chain FVIIa molecule, comprising FVII light chain (61-212) and FVII heavy chain (213-466), linked by disulfide bonds.

Literature References