factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides

Stable Identifier
R-HSA-140599
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
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factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides
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Activated thrombin cleaves the A chains of factor XIII tetramers in a reaction stimulated by the presence of fibrin multimers (Lewis et al. 1985). The amino terminal portions of the A chains are released as activation peptides, which have no known function. The resulting factor XIII tetramer remains catalytically inactive.

Literature References
PubMed ID Title Journal Year
2866798 Regulation of formation of factor XIIIa by its fibrin substrates

Lewis, SD, Janus, TJ, Lorand, L, Shafer, JA

Biochemistry 1985
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
Physical Entity
activated thrombin (factor IIa) [extracellular region]
Activity
serine-type endopeptidase activity (0004252)
This event is regulated
Negatively by
Positively by
Orthologous Events
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factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Danio rerio)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Gallus gallus)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Mus musculus)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Rattus norvegicus)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Sus scrofa)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Xenopus tropicalis)
Authored
D'Eustachio, P  (2004-08-24)
Created
D'Eustachio, P  (2004-08-24)