Reactome | Arachidonate is oxidised to PGG2 by PTGS1

Arachidonate is oxidised to PGG2 by PTGS1

Stable Identifier

R-HSA-140355

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

Synonyms

(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => prostaglandin G2, Arachidonate oxidised to PGG2

ReviewStatus

5/5

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - COX reactions (Homo sapiens)
      - Arachidonate is oxidised to PGG2 by PTGS1 (Homo sapiens)
- Metabolism of lipids (Homo sapiens)
  - Fatty acid metabolism (Homo sapiens)
    - Arachidonate metabolism (Homo sapiens)
      - Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
        
        Arachidonate is oxidised to PGG2 by PTGS1 (Homo sapiens)

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Arachidonate is oxidised to PGG2 by PTGS1

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Prostaglandin G/H synthase PTGS1 exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The cyclooxygenase function catalyzes the initial conversion of arachidonate to an intermediate, prostaglandin G2 (PGG2) (Hamberg et al. 1974, Nugteren 1973).

Literature References

PubMed ID	Title	Journal	Year
4776443	Isolation and properties of intermediates in prostaglandin biosynthesis Nugteren, DH, Hazelhof, E	Biochim Biophys Acta	1973
4521806	Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation Hamberg, M, Svensson, J, Wakabayashi, T, Samuelsson, B	Proc Natl Acad Sci U S A	1974