Reactome | FIGF [extracellular region]

FIGF [extracellular region]

Stable Identifier

R-HSA-139888

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

VEGFD, Vascular endothelial growth factor D precursor, c-fos induced growth factor

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
    - Platelet degranulation (Homo sapiens)
      - Exocytosis of platelet alpha granule contents (Homo sapiens)
        
        Platelet alpha granule contents [extracellular region] (Homo sapiens)
        
        VEGFs [extracellular region] (Homo sapiens)
        
        FIGF [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43915 VEGFD

Gene Names

VEGFD, FIGF

Chain

signal peptide:1-21, propeptide:22-88, chain:89-205, propeptide:206-354

Reference Genes

BioGPS Gene:2277 VEGFD

COSMIC (genes):VEGFD VEGFD

CTD Gene:2277 VEGFD

dbSNP Gene:2277 VEGFD

ENSEMBL:ENSG00000165197 VEGFD

ENSEMBL_homo_sapiens_GENE:ENSG00000165197.5 VEGFD

HGNC:3708 VEGFD

KEGG Gene (Homo sapiens):2277 VEGFD

Monarch:2277 VEGFD

NCBI Gene:2277 VEGFD

OMIM:300091 VEGFD

UCSC:O43915 VEGFD

Reference Transcript

RefSeq:NM_004469.4 VEGFD

Other Identifiers

11727062_at

1958_at

206742_PM_at

206742_at

2277

4000539

4000540

4000542

4000543

4000545

4000546

4000550

4000551

4000552

4000553

4000557

4000558

4000559

8171427

A_23_P45185

GE81400

GO:0001525

GO:0001666

GO:0001934

GO:0001938

GO:0002040

GO:0002376

GO:0005161

GO:0005172

GO:0005515

GO:0005576

GO:0005615

GO:0008083

GO:0008284

GO:0009617

GO:0016020

GO:0023052

GO:0030154

GO:0031093

GO:0031410

GO:0036211

GO:0038084

GO:0042056

GO:0042802

GO:0043185

GO:0043226

GO:0045766

GO:0048010

GO:0048018

GO:0048144

GO:0048856

GO:0048870

GO:0050918

GO:0050930

GO:0051781

GO:0060754

GO:0071542

GO:0098772

HMNXSV003014072

ILMN_1707612

PH_hs_0001099

TC0X002326.hg

g4758377_3p_at

p33727

Participates

as a member of

as a component of

VEGFD dimer [extracellular region] (Homo sapiens)

Other forms of this molecule

FIGF [platelet alpha granule lumen]

Inferred To

Vegfd [extracellular region] (Mus musculus)

Vegfd [extracellular region] (Rattus norvegicus)

vegfd [extracellular region] (Danio rerio)

vegfd [extracellular region] (Xenopus tropicalis)

VEGFD [extracellular region] (Bos taurus)

VEGFD [extracellular region] (Canis familiaris)

VEGFD [extracellular region] (Gallus gallus)

VEGFD [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_004460.1

OpenTargets

ENSG00000165197

HPA

ENSG00000165197-VEGFD

GeneCards

O43915

Ensembl

ENSG00000165197, ENSP00000297904, ENST00000297904

PRO

O43915

Pharos - Targets

O43915

PDB

2XV7

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.488	4