The prolactin receptor (PRLR) peptide is a single transmembrane domain protein that functions as a dimer. Recent reports suggest that like many other cytokine receptors, the prolactin receptor (PRLR) pre-assembles at the plasma membrane in the absence of ligand (Gadd & Clevenger 2006, Tallet et al. 2011), suggesting that ligand-induced activation involves conformational changes in the preformed receptor dimer (Broutin et al. 2010).
Clevenger, CV, Gadd, SL
Ayoub, MA, Zhang, C, Fernandez, I, Goffin, V, Tallet, E, Gregor, N, Trinquet, E, Salsac, M, Pin, JP
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