Reactome | PRLR:JAK2 dimerizes

PRLR:JAK2 dimerizes

Stable Identifier

R-HSA-1364044

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The prolactin receptor (PRLR) peptide is a single transmembrane domain protein that functions as a dimer. Recent reports suggest that like many other cytokine receptors, the prolactin receptor (PRLR) pre-assembles at the plasma membrane in the absence of ligand (Gadd & Clevenger 2006, Tallet et al. 2011), suggesting that ligand-induced activation involves conformational changes in the preformed receptor dimer (Broutin et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
16840534	Ligand-independent dimerization of the human prolactin receptor isoforms: functional implications Gadd, SL, Clevenger, CV	Mol Endocrinol	2006
22649370	Investigation of prolactin receptor activation and blockade using time-resolved fluorescence resonance energy transfer Tallet, E, Fernandez, I, Zhang, C, Salsac, M, Gregor, N, Ayoub, MA, Pin, JP, Trinquet, E, Goffin, V	Front Endocrinol (Lausanne)	2011