p130 (RBL2) binds Cyclin E/A:CDK2

Stable Identifier
R-HSA-1363306
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p130 (RBL2) binds Cyclin E/A:CDK2
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p130 (RBL2) is able to bind complexes of CDK2 with either cyclin A or cyclin E through the cyclin-binding LFG motif within the pocket domain, which is conserved in p107 (RBL1) and p21/WAF1/Cip1 family of cyclin-dependent kinases. In addition to LFG motif, amino terminal region of p130 (RBL2), conserved in p107 (RBL1), is necessary for inhibition of CDK2 kinase activity. Presence of E2F is not required for this interaction.
Literature References
PubMed ID Title Journal Year
9199292 p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

Dynlacht, BD, Sánchez, I, Woo, MS

Mol Cell Biol 1997
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Orthologous Events
p130 (RBL2) binds Cyclin E/A:CDK2 (Bos taurus)
p130 (RBL2) binds Cyclin E/A:CDK2 (Caenorhabditis elegans)
p130 (RBL2) binds Cyclin E/A:CDK2 (Canis familiaris)
p130 (RBL2) binds Cyclin E/A:CDK2 (Dictyostelium discoideum)
p130 (RBL2) binds Cyclin E/A:CDK2 (Drosophila melanogaster)
p130 (RBL2) binds Cyclin E/A:CDK2 (Gallus gallus)
p130 (RBL2) binds Cyclin E/A:CDK2 (Mus musculus)
p130 (RBL2) binds Cyclin E/A:CDK2 (Rattus norvegicus)
p130 (RBL2) binds Cyclin E/A:CDK2 (Sus scrofa)
p130 (RBL2) binds Cyclin E/A:CDK2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2011-06-14)
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