RNF41 ubiquitinates ERBB3

Stable Identifier
R-HSA-1358790
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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RNF41 ubiquitinates ERBB3
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RNF41 ubiquitinates unstimulated ERBB3, targeting it for degradation and regulating ERBB3 level in the cell.

Literature References
PubMed ID Title Journal Year
17210635 Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1

Carraway KL, 3rd, Cao, Z, Sweeney, C, Wu, X, Yen, L

Mol Cell Biol 2007
Participants
Input
Output
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of ERBB3:RNF41 [plasma membrane]

Physical Entity
ERBB3:RNF41 [plasma membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
RNF41 ubiquitinates ERBB3 (Bos taurus)
RNF41 ubiquitinates ERBB3 (Danio rerio)
RNF41 ubiquitinates ERBB3 (Drosophila melanogaster)
RNF41 ubiquitinates ERBB3 (Gallus gallus)
RNF41 ubiquitinates ERBB3 (Mus musculus)
RNF41 ubiquitinates ERBB3 (Rattus norvegicus)
RNF41 ubiquitinates ERBB3 (Sus scrofa)
RNF41 ubiquitinates ERBB3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-06-02)
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