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FXN(42-210) [mitochondrial inner membrane]
Stable Identifier
R-HSA-1299454
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
FXN, Frataxin, intermediate, FRDA_HUMAN
Locations in the PathwayBrowser
Expand all
Protein localization (Homo sapiens)
Mitochondrial protein import (Homo sapiens)
MPP cleaves targeting peptide (presequence) of matrix precursors (Homo sapiens)
TIMM23 PAM:Cargo [mitochondrial inner membrane] (Homo sapiens)
Cargo of TIMM23 PAM [mitochondrial inner membrane] (Homo sapiens)
FXN(42-210) [mitochondrial inner membrane] (Homo sapiens)
TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)
TIMM23 PAM:Cargo [mitochondrial inner membrane] (Homo sapiens)
Cargo of TIMM23 PAM [mitochondrial inner membrane] (Homo sapiens)
FXN(42-210) [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16595 FXN
Gene Names
FXN, FRDA, X25
Chain
transit peptide:1-41, chain:42-210, chain:56-210, chain:78-210, chain:81-210, chain:81-210
Reference Genes
BioGPS Gene:2395 FXN
COSMIC (genes):FXN FXN
CTD Gene:2395 FXN
dbSNP Gene:2395 FXN
ENSEMBL:ENSG00000165060 FXN
HGNC:3951 FXN
KEGG:hsa:2395 FXN
Monarch:2395 FXN
NCBI Gene:2395 FXN
OMIM:606829 FXN
UCSC:Q16595 FXN
Reference Transcript
RefSeq:NM_000144.4 FXN
RefSeq:NM_181425.2 FXN
RefSeq:NM_001161706.1 FXN
Other Identifiers
11732322_at
11732323_at
17085672
205565_PM_s_at
205565_s_at
230234_PM_at
230234_at
2395
3169711
3169712
3169713
3169714
3173833
3173834
3173835
3173836
3173841
3173842
3173843
3173873
3173874
3173875
3173877
33202_f_at
3573373
63549_at
70085_f_at
8155699
A_14_P136793
A_23_P60517
A_33_P3319161
GE62283
GE901387
GO:0003824
GO:0004322
GO:0005515
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0006091
GO:0006119
GO:0006783
GO:0006826
GO:0006879
GO:0007005
GO:0007628
GO:0008198
GO:0008199
GO:0008284
GO:0009060
GO:0009792
GO:0010039
GO:0010722
GO:0016226
GO:0016491
GO:0016540
GO:0018283
GO:0019230
GO:0030307
GO:0034551
GO:0034986
GO:0035265
GO:0040015
GO:0043066
GO:0043085
GO:0043226
GO:0044571
GO:0044572
GO:0046621
GO:0046716
GO:0046872
GO:0048856
GO:0050877
GO:0051349
GO:0051537
GO:0051604
GO:0065003
GO:0070301
GO:0090201
GO:0099128
GO:0140104
GO:1904231
GO:1904234
GO:1990229
HMNXSV003005750
HMNXSV003048551
Hs.20685.0.A1_3p_at
ILMN_1774826
ILMN_2342515
PH_hs_0001786
PH_hs_0029881
TC09000318.hg
U43747_s_at
g4503784_3p_at
Participates
as a candidate of
Cargo of TIMM23 PAM [mitochondrial inner membrane] (Homo sapiens)
Other forms of this molecule
FXN(81-210) [mitochondrial matrix]
FXN(1-41) [mitochondrial matrix]
FXN(1-210) [mitochondrial inner membrane]
FXN(1-210) [mitochondrial intermembrane space]
FXN(42-210) [mitochondrial matrix]
Cross References
RefSeq
NP_000135.2
,
NP_001155178.1
,
NP_852090.1
OpenTargets
ENSG00000165060
ENSEMBL
ENST00000484259
,
ENSP00000379652
,
ENST00000396366
,
ENSP00000419243
HPA
ENSG00000165060-FXN
PRO
Q16595
Pharos - Targets
Q16595
Orphanet
FXN
HMDB Protein
HMDBP02901
PDB
5KZ5
,
1EKG
,
3S5E
,
3T3X
,
3T3T
,
1LY7
,
8PK9
,
3T3L
,
8PK8
,
6NZU
,
3S4M
,
3T3K
,
3T3J
,
3S5F
,
3S5D
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UN19 DAPP1
2
p-Y139-DAPP1 [plasma membrane]
(R-HSA-1112650)
DAPP1 [cytosol]
(R-HSA-197950)
0.718
6
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
3
UniProt:Q9BVU5 Q9BVU5
0.556
3
UniProt:Q92828 COR2A
0.556
3
UniProt:Q8N6K7-2 SAMD3
0.556
3
UniProt:Q9NS23-4 RASSF1
0.556
3
UniProt:Q9GZS3 SKIC8
2
WDR61 [cytosol]
(R-HSA-8931534)
WDR61 [nucleoplasm]
(R-HSA-8866696)
0.556
3
UniProt:Q9HC96 CAPN10
1
CAPN10 [cytosol]
(R-HSA-8848640)
0.556
3
UniProt:Q8WVD3 RNF138
1
RNF138 [cytosol]
(R-HSA-976008)
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:Q96D59 RN183
0.556
3
UniProt:acpP A0A437HBF4
0.488
2
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