Reactome | Activation of Potassium transport channels

Activation of Potassium transport channels

Stable Identifier

R-HSA-1296045

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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Activation of Potassium transport channels

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Homotetramers of Kir 1.1 function as inwardly rectifying potassium transport channels. Ki 1.1 are found on the apical side of the cells in the ascending limp of loop of henle and upon activation transport K+ into the extracellular space. Heterotetramers of Kir 4.1 and Ki 5.1 are found on the basolateral side of cells in the distal convoluted tube. Activation of kir 4.1 and 5.1 heterotetramers leads to efflux of K+ into the extracellular space.

Literature References

PubMed ID	Title	Journal	Year
19221509	The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating Fallen, K, Banerjee, S, Sheehan, J, Addison, D, Lewis, LM, Meiler, J, Denton, JS	Channels (Austin)	2009