IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5

Stable Identifier
R-HSA-1295540
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5 phosphorylates STAT5
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Signal transducer and activator of transcription 5A or 5B (STAT5A and/or STAT5B, typically referred to as STAT5) are phosphorylated after Interleukin‑7 (IL7) ligand‑receptor interaction (Foxwell et al. 1995, van der Plas et al. 1996, Yu et al. 1998, Jufrroy et al. 2010, Landires et al. 2011).

STAT5 is activated in COS7 cells when co‑transfected with JAK3 (Lin et al. 1996), though this does not demonstrate that JAK3 phosphorylates STAT5 proteins in response to IL7 in vivo (Lin & Leonard, 2000). STAT5 phosphorylation is represented here as a black box event because it is not clear which JAK kinase phosphorylates STAT5 in vivo.

Literature References
PubMed ID Title Journal Year
8709637 Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain

van der Plas, DC, Smiers, F, Pouwels, K, Hoefsloot, LH, Löwenberg, B, Touw, IP

Leukemia 1996
19864382 Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway

Juffroy, O, Bugault, F, Lambotte, O, Landires, I, Viard, JP, Niel, L, Fontanet, A, Delfraissy, JF, Thèze, J, Chakrabarti, LA

J. Virol. 2010
9715265 Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells

Yu, CR, Young, HA, Ortaldo, JR

J Leukoc Biol 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created