Reactome | IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5

IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5

Stable Identifier

R-HSA-1295540

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5 phosphorylates STAT5

ReviewStatus

5/5

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IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5

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Signal transducer and activator of transcription 5A or 5B (STAT5A and/or STAT5B, typically referred to as STAT5) are phosphorylated after Interleukin‑7 (IL7) ligand‑receptor interaction (Foxwell et al. 1995, van der Plas et al. 1996, Yu et al. 1998, Jufrroy et al. 2010, Landires et al. 2011).

STAT5 is activated in COS7 cells when co‑transfected with JAK3 (Lin et al. 1996), though this does not demonstrate that JAK3 phosphorylates STAT5 proteins in response to IL7 in vivo (Lin & Leonard, 2000). STAT5 phosphorylation is represented here as a black box event because it is not clear which JAK kinase phosphorylates STAT5 in vivo.

Literature References

PubMed ID	Title	Journal	Year
19864382	Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway Juffroy, O, Bugault, F, Lambotte, O, Landires, I, Viard, JP, Niel, L, Fontanet, A, Delfraissy, JF, Thèze, J, Chakrabarti, LA	J. Virol.	2010
8709637	Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain van der Plas, DC, Smiers, F, Pouwels, K, Hoefsloot, LH, Löwenberg, B, Touw, IP	Leukemia	1996
9715265	Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells Yu, CR, Young, HA, Ortaldo, JR	J Leukoc Biol	1998