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Developmental Biology
Stable Identifier
R-HSA-1266738
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
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Developmental biology seeks to understand the array of processes by which a fertilized egg gives rise to the diverse tissues of the adult body. Examples of several developmental processes have been annotated here. In the early embryo, transcriptional regulation of pluripotent stem cells, gastrulation (including NODAL signaling), and activation of HOX genes during differentiation are annotated. Annotations of later, more specialized processes include nervous system development, cardiogenesis, aspects of the roles of cell adhesion molecules in axonal guidance and myogenesis, transcriptional regulation in pancreatic beta cells, adipogenesis, transcriptional regulation of granulopoeisis, transcriptional regulation of testis differentiation, LGI-ADAM interactions, and keratinization.
Transitions between cell types and cell states in developmental and differentiation processes are annotated as developmental cell lineages.
Participants
Events
Maternal to zygotic transition (MZT)
(Homo sapiens)
Transcriptional regulation of pluripotent stem cells
(Homo sapiens)
Gastrulation
(Homo sapiens)
Signaling by NODAL
(Homo sapiens)
Activation of HOX genes during differentiation
(Homo sapiens)
Nervous system development
(Homo sapiens)
LGI-ADAM interactions
(Homo sapiens)
Myogenesis
(Homo sapiens)
Cardiogenesis
(Homo sapiens)
Kidney development
(Homo sapiens)
Regulation of beta-cell development
(Homo sapiens)
Transcriptional regulation of testis differentiation
(Homo sapiens)
Keratinization
(Homo sapiens)
Transcriptional regulation of granulopoiesis
(Homo sapiens)
Developmental Cell Lineages
(Homo sapiens)
MITF-M-regulated melanocyte development
(Homo sapiens)
Adipogenesis
(Homo sapiens)
Orthologous Events
Developmental Biology (Bos taurus)
Developmental Biology (Caenorhabditis elegans)
Developmental Biology (Canis familiaris)
Developmental Biology (Danio rerio)
Developmental Biology (Dictyostelium discoideum)
Developmental Biology (Drosophila melanogaster)
Developmental Biology (Gallus gallus)
Developmental Biology (Mus musculus)
Developmental Biology (Plasmodium falciparum)
Developmental Biology (Rattus norvegicus)
Developmental Biology (Saccharomyces cerevisiae)
Developmental Biology (Schizosaccharomyces pombe)
Developmental Biology (Sus scrofa)
Developmental Biology (Xenopus tropicalis)
Reviewed
Matthews, L (2024-02-28)
Matthews, L (2023-11-09)
Matthews, L (2023-08-22)
Matthews, L (2024-08-21)
May, B (2024-02-28)
Walmod, PS (2011-08-22)
Jensen, J (2011-08-22)
Krauss, RS (2011-08-22)
Maness, PF (2011-08-22)
Created
Orlic-Milacic, M (2011-05-06)
© 2025
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