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CRLF2 [plasma membrane]
Stable Identifier
R-HSA-1264802
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Thymic stromal lymphopoietin protein receptor, Cytokine receptor-like factor 2, CRLF2_HUMAN, TSLP receptor
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-7 signaling (Homo sapiens)
STAT3 binds TSLP:IL7R:CRLF2 (Homo sapiens)
IL7R:TSLP:CRLF2 [plasma membrane] (Homo sapiens)
CRLF2:IL7R [plasma membrane] (Homo sapiens)
CRLF2 [plasma membrane] (Homo sapiens)
IL7R:TSLP:CRLF2:STAT3 [plasma membrane] (Homo sapiens)
IL7R:TSLP:CRLF2 [plasma membrane] (Homo sapiens)
CRLF2:IL7R [plasma membrane] (Homo sapiens)
CRLF2 [plasma membrane] (Homo sapiens)
STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Homo sapiens)
IL7R:TSLP:CRLF2:STAT3 [plasma membrane] (Homo sapiens)
IL7R:TSLP:CRLF2 [plasma membrane] (Homo sapiens)
CRLF2:IL7R [plasma membrane] (Homo sapiens)
CRLF2 [plasma membrane] (Homo sapiens)
IL7R:TSLP:CRLF2:p-STAT3 [plasma membrane] (Homo sapiens)
IL7R:TSLP:CRLF2 [plasma membrane] (Homo sapiens)
CRLF2:IL7R [plasma membrane] (Homo sapiens)
CRLF2 [plasma membrane] (Homo sapiens)
TSLP binds CRLF2:IL7R (Homo sapiens)
CRLF2:IL7R [plasma membrane] (Homo sapiens)
CRLF2 [plasma membrane] (Homo sapiens)
IL7R:TSLP:CRLF2 [plasma membrane] (Homo sapiens)
CRLF2:IL7R [plasma membrane] (Homo sapiens)
CRLF2 [plasma membrane] (Homo sapiens)
p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Homo sapiens)
IL7R:TSLP:CRLF2 [plasma membrane] (Homo sapiens)
CRLF2:IL7R [plasma membrane] (Homo sapiens)
CRLF2 [plasma membrane] (Homo sapiens)
IL7R:TSLP:CRLF2:p-STAT3 [plasma membrane] (Homo sapiens)
IL7R:TSLP:CRLF2 [plasma membrane] (Homo sapiens)
CRLF2:IL7R [plasma membrane] (Homo sapiens)
CRLF2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HC73 CRLF2
Gene Names
CRLF2, CRL2, ILXR, TSLPR
Chain
signal peptide:1-22, chain:23-371
Reference Genes
BioGPS Gene:64109 CRLF2
COSMIC (genes):CRLF2 CRLF2
CTD Gene:64109 CRLF2
dbSNP Gene:64109 CRLF2
ENSEMBL:ENSG00000205755 CRLF2
ENSEMBL_homo_sapiens_GENE:ENSG00000205755.13 CRLF2
ENSEMBL_homo_sapiens_GENE:ENSG00000292363.1 CRLF2
HGNC:14281 CRLF2
KEGG Gene (Homo sapiens):64109 CRLF2
Monarch:64109 CRLF2
NCBI Gene:64109 CRLF2
OMIM:300357 CRLF2
OMIM:400023 CRLF2
UCSC:Q9HC73 CRLF2
Reference Transcript
RefSeq:NM_001012288.2 CRLF2
RefSeq:NM_022148.3 CRLF2
Other Identifiers
11738480_a_at
11738918_a_at
17108694
208303_PM_s_at
208303_s_at
4056209
4056210
4056211
4056212
4056213
64109
8171105
A_23_P113237
A_33_P3298139
GE82667
GO:0002376
GO:0004896
GO:0005515
GO:0005576
GO:0005886
GO:0008284
GO:0009897
GO:0016020
GO:0019221
GO:0019955
GO:0023052
GO:0032754
GO:0033005
GO:0043235
GO:0060089
GO:1904894
HMNXSV003036485
ILMN_1788655
ILMN_1795304
PH_hs_0028120
TC0X002305.hg
TC0Y000347.hg
g13375623_3p_a_at
Participates
as a component of
CRLF2:IL7R [plasma membrane] (Homo sapiens)
Inferred To
CRLF2 [plasma membrane]
(Canis familiaris)
CRLF2 [plasma membrane]
(Gallus gallus)
Ghost homologue of CRLF2 [plasma membrane]
(Bos taurus)
Ghost homologue of CRLF2 [plasma membrane]
(Mus musculus)
Ghost homologue of CRLF2 [plasma membrane]
(Rattus norvegicus)
LOC110257900 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_071431.2
,
NP_001012288.2
Guide to Pharmacology - Targets
1704
OpenTargets
ENSG00000205755
GeneCards
Q9HC73
HPA
ENSG00000205755-CRLF2
Ensembl
ENSP00000370979
,
ENST00000381567
,
ENSG00000205755
,
ENST00000400841
,
ENSP00000383641
PRO
Q9HC73
Pharos - Targets
Q9HC73
PDB
5J11
,
5J12
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