Reactome | ERBB4s80 binds YAP1

ERBB4s80 binds YAP1

Stable Identifier

R-HSA-1254251

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ERBB4s80 interacts with a co-transcriptional activator YAP1 through its WW-domain binding motifs in the C-tail. Feng et al. established that the PY2 motif, present in CYT1 isoforms of ERBB4 only, has the highest affinity for YAP1 binding. PY1 and PY3 motifs, shared between CYT1 and CYT2 isoforms, have lower binding affinity for YAP1, with PY1 motif being the least important for YAP1 interaction (Komuro et al. 2003, Omerovic et al. 2004, Feng et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19047365	The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation Feng, SM, Muraoka-Cook, RS, Hunter, D, Sandahl, MA, Caskey, LS, Miyazawa, K, Atfi, A, Earp HS, 3rd	Mol Cell Biol	2009
12807903	WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus Komuro, A, Nagai, M, Navin, NE, Sudol, M	J Biol Chem	2003
15023535	Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level Omerovic, J, Puggioni, EM, Napoletano, S, Visco, V, Fraioli, R, Frati, L, Gulino, A, Alimandi, M	Exp Cell Res	2004