Reactome | SHC1 phosphorylation by ERBB2 heterodimers

SHC1 phosphorylation by ERBB2 heterodimers

Stable Identifier

R-HSA-1250195

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

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SHC1 phosphorylation by ERBB2 heterodimers

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Once bound to ERBB2 heterodimers, SHC1 is phosphorylated on tyrosine residues by the tyrosine kinase activity of either ERBB2 or its heterodimerization partners EGFR and ERBB4 (Segatto et al. 1993, Soler et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
8036006	Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites Soler, C, Alvarez, CV, Beguinot, L, Carpenter, G	Oncogene	1994
8101647	Shc products are substrates of erbB-2 kinase Segatto, O, Pelicci, G, Giuli, S, Digiesi, G, Di Fiore, PP, McGlade, J, Pawson, T, Pelicci, PG	Oncogene	1993