SHC1 phosphorylation by ERBB2 heterodimers

Stable Identifier
R-HSA-1250195
Type
Reaction
Species
Homo sapiens
Compartment
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Once bound to ERBB2 heterodimers, SHC1 is phosphorylated on tyrosine residues by the tyrosine kinase activity of either ERBB2 or its heterodimerization partners EGFR and ERBB4 (Segatto et al. 1993, Soler et al. 1994).

Literature References
PubMed ID Title Journal Year
8101647 Shc products are substrates of erbB-2 kinase

Pawson, T, Di Fiore, PP, Giuli, S, Pelicci, G, Digiesi, G, McGlade, J, Pelicci, PG, Segatto, O

Oncogene 1993
8036006 Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites

Alvarez, CV, Soler, C, Beguinot, L, Carpenter, G

Oncogene 1994
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane]

Orthologous Events
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