Once bound to ERBB2 heterodimers, SHC1 is phosphorylated on tyrosine residues by the tyrosine kinase activity of either ERBB2 or its heterodimerization partners EGFR and ERBB4 (Segatto et al. 1993, Soler et al. 1994).
Di Fiore, PP,
protein tyrosine kinase activity of SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane]