SHC1 phosphorylation by ERBB2 heterodimers

Stable Identifier
R-HSA-1250195
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Once bound to ERBB2 heterodimers, SHC1 is phosphorylated on tyrosine residues by the tyrosine kinase activity of either ERBB2 or its heterodimerization partners EGFR and ERBB4 (Segatto et al. 1993, Soler et al. 1994).

Literature References
PubMed ID Title Journal Year
8036006 Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites

Soler, C, Alvarez, CV, Beguinot, L, Carpenter, G

Oncogene 1994
8101647 Shc products are substrates of erbB-2 kinase

Segatto, O, Pelicci, G, Giuli, S, Digiesi, G, Di Fiore, PP, McGlade, J, Pawson, T, Pelicci, PG

Oncogene 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created