Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody

Stable Identifier
R-HSA-1248677
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody
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Cetuximab binds to the extracellular domain of EGFR and blocks ligand binding, leading to receptor inactivation, internalization and degradation. Cetuximab is approved for combination therapy and monotherapy of metastatic colorectal cancer and advanced squamous cell carcinoma of head and neck in patients whose tumors over-express wild-type EGFR protein, usually due to amplification of EGFR gene.
Literature References
PubMed ID Title Journal Year
15269313 Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

Bleiberg, H, Humblet, Y, Mueser, M, Khayat, D, Chau, I, Cunningham, D, Bets, D, Verslype, C, Santoro, A, Harstrick, A, Siena, S, Van Cutsem, E

N Engl J Med 2004
15837620 Structural basis for inhibition of the epidermal growth factor receptor by cetuximab

Ferguson, KM, Wiltzius, JJW, Schmitz, KR, Li, S, Kussie, P, Jeffrey, PD

Cancer Cell 2005
16314626 Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study

Forastiere, AA, Burtness, B, Eastern Cooperative Oncology, Group, Flood, W, Goldwasser, MA, Mattar, B

J Clin Oncol 2005
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
head and neck squamous cell carcinoma DOID:5520 carcinoma of the head and neck, squamous cell carcinoma of the head and neck
large intestine cancer DOID:5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2011-04-12)
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