Reactome | SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-

SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-

Stable Identifier

R-HSA-1247665

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic chloride for extracellular bicarbonate

ReviewStatus

5/5

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SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-

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The band 3 anion exchange protein (AE1, SLC4A1) exchanges chloride (Cl-) for bicarbonate (HCO3-) across the plasma membrane according to the concentration gradients of the anions (Knauf et al. 1996, Dahl et al. 2003). SLC4A1 may be part of a complex ("metabolon") with carbonic anhydrase II (CA2) which would facilitate the transport of HCO3- (Sterling et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
12933803	Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer Stuart-Tilley, AK, Alper, SL, Shmukler, BE, Jiang, L, Chernova, MN, Dahl, NK	J Biol Chem	2003
11606574	A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers Sterling, D, Reithmeier, RA, Casey, JR	J Biol Chem	2001
8972395	The asymmetry of chloride transport at 38 degrees C in human red blood cell membranes Gasbjerg, PK, Brahm, J, Knauf, PA	J Gen Physiol	1996