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HP-HIF3A [nucleoplasm]
Stable Identifier
R-HSA-1234140
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hydroxyPro492-HIF3A, HIF3A with hydroxyproline-492, Hypoxia-inducible factor 3 alpha, HIF3A_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Homo sapiens)
HP-HIF3A [nucleoplasm] (Homo sapiens)
Nuclear VBC complex ubiquitinylates HIF-alpha (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
HP-HIF3A [nucleoplasm] (Homo sapiens)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
ub-hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
HP-HIF3A [nucleoplasm] (Homo sapiens)
Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
HP-HIF3A [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
HP-HIF3A [nucleoplasm] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
ub-hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
HP-HIF3A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2N7 HIF3A
Gene Names
HIF3A, BHLHE17, MOP7, PASD7
Chain
chain:1-669
Reference Genes
BioGPS Gene:64344 HIF3A
COSMIC (genes):HIF3A HIF3A
CTD Gene:64344 HIF3A
dbSNP Gene:64344 HIF3A
ENSEMBL:ENSG00000124440 HIF3A
HGNC:15825 HIF3A
KEGG:hsa:64344 HIF3A
Monarch:64344 HIF3A
NCBI Gene:64344 HIF3A
OMIM:609976 HIF3A
UCSC:Q9Y2N7 HIF3A
Reference Transcript
RefSeq:NM_152795.3 HIF3A
RefSeq:NM_022462.4 HIF3A
RefSeq:NM_152794.3 HIF3A
Participates
as a member of
hydroxyPro-HIF-alpha [nucleoplasm] (Homo sapiens)
as an output of
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Homo sapiens)
Other forms of this molecule
HIF3A [cytosol]
HP-HIF3A [cytosol]
HIF3A [nucleoplasm]
Inferred To
Hif3a [nucleoplasm]
(Mus musculus)
Hif3a [nucleoplasm]
(Rattus norvegicus)
HIF3A [nucleoplasm]
(Bos taurus)
HIF3A [nucleoplasm]
(Canis familiaris)
HIF3A [nucleoplasm]
(Sus scrofa)
sima [nucleoplasm]
(Drosophila melanogaster)
hif1a [nucleoplasm]
(Xenopus tropicalis)
hif-1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of HP-HIF3A [nucleoplasm]
(Danio rerio)
hif1aa [nucleoplasm]
(Danio rerio)
hif1ab [nucleoplasm]
(Danio rerio)
HP-HIF3A [nucleoplasm]
(Gallus gallus)
Modified Residues
Name
monohydroxylated proline at 492
Coordinate
492
PsiMod Name
monohydroxylated proline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.
Cross References
ENSEMBL
ENSP00000366898
,
ENST00000244303
,
ENSP00000244303
,
ENST00000300862
,
ENSP00000300862
,
ENST00000377670
,
ENSG00000124440
OpenTargets
ENSG00000124440
GeneCards
HIF3A
HPA
ENSG00000124440-HIF3A
PRO
Q9Y2N7
Pharos - Targets
Q9Y2N7
PDB
4WN5
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