Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants

Stable Identifier
R-HSA-1226012
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants
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EGFR cancer mutants are assumed to recruit the PI3K complex PIK3CA:PIK3R1 in a manner similar to wild-type EGFR.
Literature References
PubMed ID Title Journal Year
15284455 Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

Bell, DW, Sordella, R, Haber, DA, Settleman, J

Science 2004
Participants
Input
Output
Participates
as an event of
Normal reaction
PI3K binds to EGF:EGFR:GRB2:GAB1 (Homo sapiens)
Functional status

Gain of function of Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2011-03-04)
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