Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants

Stable Identifier
R-HSA-1226012
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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EGFR cancer mutants are assumed to recruit the PI3K complex PIK3CA:PIK3R1 in a manner similar to wild-type EGFR.

Literature References
PubMed ID Title Journal Year
15284455 Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

Sordella, R, Bell, DW, Haber, DA, Settleman, J

Science 2004
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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