Nitrosoglutathione gets cleaved to Cys(NO)-Gly

Stable Identifier
R-HSA-1222712
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Most gamma-glutamyl transpeptidases (GGT) cleave both glutathione and glutathione conjugates. Mtb GGT cleaves nitrosoglutathione )GSNO) to Cys(NO)-Gly, thus making it soluble for transport into the cytosol (Dayaram et al. 2006).

Literature References
PubMed ID Title Journal Year
16452418 Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione

Dayaram, YK, Talaue, MT, Connell, ND, Venketaraman, V

J Bacteriol 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione hydrolase activity of GgtA [periplasmic space]
Physical Entity
Activity
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created