Nitrosoglutathione gets cleaved to Cys(NO)-Gly

Stable Identifier
R-HSA-1222712
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
periplasmic space
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Nitrosoglutathione gets cleaved to Cys(NO)-Gly
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Most gamma-glutamyl transpeptidases (GGT) cleave both glutathione and glutathione conjugates. Mtb GGT cleaves nitrosoglutathione )GSNO) to Cys(NO)-Gly, thus making it soluble for transport into the cytosol (Dayaram et al. 2006).

Literature References
PubMed ID Title Journal Year
16452418 Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione

Dayaram, YK, Talaue, MT, Connell, ND, Venketaraman, V

J Bacteriol 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glutathione hydrolase activity of GgtA [periplasmic space]
Physical Entity
GgtA [periplasmic space]
Activity
glutathione hydrolase activity (0036374)
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Target Pathogen
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
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