Nitrosoglutathione gets cleaved to Cys(NO)-Gly

Stable Identifier
R-HSA-1222712
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
periplasmic space
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Nitrosoglutathione gets cleaved to Cys(NO)-Gly
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Most gamma-glutamyl transpeptidases (GGT) cleave both glutathione and glutathione conjugates. Mtb GGT cleaves nitrosoglutathione )GSNO) to Cys(NO)-Gly, thus making it soluble for transport into the cytosol (Dayaram et al. 2006).
Literature References
PubMed ID Title Journal Year
16452418 Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione

Connell, ND, Venketaraman, V, Talaue, MT, Dayaram, YK

J Bacteriol 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glutathione hydrolase activity of GgtA [periplasmic space]

Physical Entity
GgtA [periplasmic space] (Mycobacterium tuberculosis)
Activity
glutathione hydrolase activity (GO:0036374)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
Cite Us!