Nitrosoglutathione gets cleaved to Cys(NO)-Gly

Stable Identifier
R-HSA-1222712
Type
Reaction
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
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Most gamma-glutamyl transpeptidases (GGT) cleave both glutathione and glutathione conjugates. Mtb GGT cleaves nitrosoglutathione )GSNO) to Cys(NO)-Gly, thus making it soluble for transport into the cytosol (Dayaram et al. 2006).

Literature References
PubMed ID Title Journal Year
16452418 Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione

Connell, ND, Venketaraman, V, Talaue, MT, Dayaram, YK

J Bacteriol 2006
Participants
Participates
Catalyst Activity

glutathione hydrolase activity of GgtA [periplasmic space]

Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created
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