Nitric oxide diffuses into the phagosome

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R-HSA-1222686
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Reaction
Species
Homo sapiens
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Nitric oxide diffuses into the phagosome (Clancy et al. 1994). Although NO has been shown to be critical for control of Mtb infection in mice, its role in human infection is less clear. Instead, the generation of antimicrobial defence molecules including cathelicidin in a vitamin D-dependent pathway is much better established (Fabri et al. 2011, Martineau et al. 2011).

Literature References
PubMed ID Title Journal Year
21998409 Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages

Steinmeyer, A, Stenger, S, Sieling, PA, Modlin, RL, Jo, EK, Z├╝gel, U, Iyer, SS, Hewison, M, Krutzik, SR, Hollis, BW, Cheng, G, Lewinsohn, DM, Lee, HM, Realegeno, S, Liu, PT, Adams, JS, Bloom, BR, Shin, DM, Teles, R, Bruns, H, Montoya, D, Schenk, M, Yuk, JM, Fabri, M

Sci Transl Med 2011
22025704 Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa

Oni, T, Bangani, N, Bashe, L, Martineau, AR, de Azevedo, V, Timms, PM, Tsekela, R, Nhamoyebonde, S, Rangaka, MX, Wilkinson, RJ, Wilkinson, KA, Marais, S, Caldwell, J, Venton, TR

Proc Natl Acad Sci U S A 2011
8170969 Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary

Levartovsky, D, Yegudin, J, Leszczynska-Piziak, J, Clancy, RM, Abramson, SB

Proc Natl Acad Sci U S A 1994
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