Nitric oxide diffuses into the phagosome

Stable Identifier
R-HSA-1222686
Type
Reaction [transition]
Species
Homo sapiens
Compartment
phagocytic vesicle membrane, cytosol
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Nitric oxide diffuses into the phagosome
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Nitric oxide diffuses into the phagosome (Clancy et al. 1994). Although NO has been shown to be critical for control of Mtb infection in mice, its role in human infection is less clear. Instead, the generation of antimicrobial defence molecules including cathelicidin in a vitamin D-dependent pathway is much better established (Fabri et al. 2011, Martineau et al. 2011).

Literature References
PubMed ID Title Journal Year
22025704 Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa

Martineau, AR, Nhamoyebonde, S, Oni, T, Rangaka, MX, Marais, S, Bangani, N, Tsekela, R, Bashe, L, de Azevedo, V, Caldwell, J, Venton, TR, Timms, PM, Wilkinson, KA, Wilkinson, RJ

Proc Natl Acad Sci U S A 2011
21998409 Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages

Fabri, M, Stenger, S, Shin, DM, Yuk, JM, Liu, PT, Realegeno, S, Lee, HM, Krutzik, SR, Schenk, M, Sieling, PA, Teles, R, Montoya, D, Iyer, SS, Bruns, H, Lewinsohn, DM, Hollis, BW, Hewison, M, Adams, JS, Steinmeyer, A, Zügel, U, Cheng, G, Jo, EK, Bloom, BR, Modlin, RL

Sci Transl Med 2011
8170969 Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary

Clancy, RM, Levartovsky, D, Leszczynska-Piziak, J, Yegudin, J, Abramson, SB

Proc Natl Acad Sci U S A 1994
Participants
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Participant Of
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Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)