Reactome | Nitric oxide diffuses into the phagosome

Nitric oxide diffuses into the phagosome

Stable Identifier

R-HSA-1222686

Type

Reaction [transition]

Species

Homo sapiens

Compartment

phagocytic vesicle membrane, cytosol

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Nitric oxide diffuses into the phagosome (Clancy et al. 1994). Although NO has been shown to be critical for control of Mtb infection in mice, its role in human infection is less clear. Instead, the generation of antimicrobial defence molecules including cathelicidin in a vitamin D-dependent pathway is much better established (Fabri et al. 2011, Martineau et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
22025704	Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa Martineau, AR, Nhamoyebonde, S, Oni, T, Rangaka, MX, Marais, S, Bangani, N, Tsekela, R, Bashe, L, de Azevedo, V, Caldwell, J, Venton, TR, Timms, PM, Wilkinson, KA, Wilkinson, RJ	Proc Natl Acad Sci U S A	2011
21998409	Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages Fabri, M, Stenger, S, Shin, DM, Yuk, JM, Liu, PT, Realegeno, S, Lee, HM, Krutzik, SR, Schenk, M, Sieling, PA, Teles, R, Montoya, D, Iyer, SS, Bruns, H, Lewinsohn, DM, Hollis, BW, Hewison, M, Adams, JS, Steinmeyer, A, Zügel, U, Cheng, G, Jo, EK, Bloom, BR, Modlin, RL	Sci Transl Med	2011
8170969	Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary Clancy, RM, Levartovsky, D, Leszczynska-Piziak, J, Yegudin, J, Abramson, SB	Proc Natl Acad Sci U S A	1994