Hydroperoxyl enters the bacterium

Stable Identifier
R-HSA-1222342
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Hydroperoxyl enters the bacterium
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Superoxide can enter the bacterium when acidic conditions apply. Together with a proton it forms the uncharged hydroperoxyl radical (OOH·) which is membrane permeable (Nathan & Shiloh 2000, Zahrt & Deretic 2002, Warner & Mizrahi 2006, Spagnolo et al, 2004).

Literature References
PubMed ID Title Journal Year
16847086 Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy

Warner, DF, Mizrahi, V

Clin Microbiol Rev 2006
11970850 Reactive nitrogen and oxygen intermediates and bacterial defenses: unusual adaptations in Mycobacterium tuberculosis

Zahrt, TC, Deretic, V

Antioxid Redox Signal 2002
15155722 Unique features of the sodC-encoded superoxide dismutase from Mycobacterium tuberculosis, a fully functional copper-containing enzyme lacking zinc in the active site

Spagnolo, L, Törö, I, D'Orazio, M, O'Neill, P, Pedersen, JZ, Carugo, O, Rotilio, G, Battistoni, A, Djinovic-Carugo, K

J Biol Chem 2004
10922044 Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

Nathan, C, Shiloh, MU

Proc Natl Acad Sci U S A 2000
Participants
Input
Output
Entity On Other Cell
Participant Of
hasEvent
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
Cite Us!