Superoxide can enter the bacterium when acidic conditions apply. Together with a proton it forms the uncharged hydroperoxyl radical (OOH·) which is membrane permeable (Nathan & Shiloh 2000, Zahrt & Deretic 2002, Warner & Mizrahi 2006, Spagnolo et al, 2004).
Warner, DF, Mizrahi, V
Zahrt, TC, Deretic, V
Spagnolo, L, Törö, I, D'Orazio, M, O'Neill, P, Pedersen, JZ, Carugo, O, Rotilio, G, Battistoni, A, Djinovic-Carugo, K
Nathan, C, Shiloh, MU
© 2021 Reactome