Hydroperoxyl enters the bacterium

Stable Identifier
R-HSA-1222342
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
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Hydroperoxyl enters the bacterium
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Superoxide can enter the bacterium when acidic conditions apply. Together with a proton it forms the uncharged hydroperoxyl radical (OOH·) which is membrane permeable (Nathan & Shiloh 2000, Zahrt & Deretic 2002, Warner & Mizrahi 2006, Spagnolo et al, 2004).

Literature References
PubMed ID Title Journal Year
11970850 Reactive nitrogen and oxygen intermediates and bacterial defenses: unusual adaptations in Mycobacterium tuberculosis

Zahrt, TC, Deretic, V

Antioxid Redox Signal 2002
16847086 Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy

Warner, DF, Mizrahi, V

Clin Microbiol Rev 2006
15155722 Unique features of the sodC-encoded superoxide dismutase from Mycobacterium tuberculosis, a fully functional copper-containing enzyme lacking zinc in the active site

D'Orazio, M, Törö, I, Spagnolo, L, Pedersen, JZ, Carugo, O, Rotilio, G, Battistoni, A, Djinovic-Carugo, K, O'Neill, P

J Biol Chem 2004
10922044 Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

Shiloh, MU, Nathan, C

Proc Natl Acad Sci U S A 2000
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Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
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