Phosphorylation of R-SMAD2/3 by NODAL receptor

Stable Identifier
R-HSA-1181355
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of R-SMAD2/3 by NODAL receptor
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NODAL receptors signal by phosphorylating SMAD2 and SMAD3 (Bondestam et al. 2001, Kumar et al. 2001, DaCosta Byfield et al. 2004). As in TGF-beta signaling, Smad anchor for receptor activation (SARA) may bind and present SMAD2 and SMAD3 for phosphorylation but this has not yet been demonstrated in NODAL signaling.

Literature References
PubMed ID Title Journal Year
14978253 SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7

DaCosta Byfield, S, Major, C, Roberts, AB, Laping, NJ

Mol Pharmacol 2004
12063393 cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)

Otonkoski, T, Kaivo-Oja, N, Aaltonen, J, Kallio, J, Ustinov, J, Horelli-Kuitunen, N, Fujii, M, Huotari, MA, Bondestam, J, Moren, A, Ritvos, O, ten Dijke, P, Moustakas, A

Cytogenet Cell Genet 2001
11024047 Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads

Kuehn, MR, Celeste, AJ, ten Dijke, P, Wolfman, NM, Novoselov, V, Kumar, A

J Biol Chem 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of NODAL:p-NODAL Receptor [plasma membrane]

Physical Entity
NODAL:p-NODAL Receptor [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Phosphorylation of Smad2 by Nodal Receptor (Homo sapiens)
Authored
May, B  (2011-01-27)
Reviewed
Peng, C  (2011-08-24)
Created
May, B  (2011-02-04)
Cite Us!