NODAL receptors signal by phosphorylating SMAD2 and SMAD3 (Bondestam et al. 2001, Kumar et al. 2001, DaCosta Byfield et al. 2004). As in TGF-beta signaling, Smad anchor for receptor activation (SARA) may bind and present SMAD2 and SMAD3 for phosphorylation but this has not yet been demonstrated in NODAL signaling.
Bondestam, J, Huotari, MA, Moren, A, Ustinov, J, Kaivo-Oja, N, Kallio, J, Horelli-Kuitunen, N, Aaltonen, J, Fujii, M, Moustakas, A, ten Dijke, P, Otonkoski, T, Ritvos, O
DaCosta Byfield, S, Major, C, Laping, NJ, Roberts, AB
Kumar, A, Novoselov, V, Celeste, AJ, Wolfman, NM, ten Dijke, P, Kuehn, MR
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