Phosphorylation of R-SMAD2/3 by NODAL receptor

Stable Identifier
R-HSA-1181355
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Phosphorylation of R-SMAD2/3 by NODAL receptor
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NODAL receptors signal by phosphorylating SMAD2 and SMAD3 (Bondestam et al. 2001, Kumar et al. 2001, DaCosta Byfield et al. 2004). As in TGF-beta signaling, Smad anchor for receptor activation (SARA) may bind and present SMAD2 and SMAD3 for phosphorylation but this has not yet been demonstrated in NODAL signaling.

Literature References
PubMed ID Title Journal Year
12063393 cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)

Bondestam, J, Huotari, MA, Moren, A, Ustinov, J, Kaivo-Oja, N, Kallio, J, Horelli-Kuitunen, N, Aaltonen, J, Fujii, M, Moustakas, A, ten Dijke, P, Otonkoski, T, Ritvos, O

Cytogenet Cell Genet 2001
14978253 SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7

DaCosta Byfield, S, Major, C, Laping, NJ, Roberts, AB

Mol Pharmacol 2004
11024047 Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads

Kumar, A, Novoselov, V, Celeste, AJ, Wolfman, NM, ten Dijke, P, Kuehn, MR

J Biol Chem 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of NODAL:p-NODAL Receptor [plasma membrane]
Physical Entity
NODAL:p-NODAL Receptor [plasma membrane]
Activity
protein serine/threonine kinase activity (0004674)
Inferred From
Phosphorylation of Smad2 by Nodal Receptor (Homo sapiens)
Authored
May, B  (2011-01-28)
Reviewed
Peng, C  (2011-08-25)
Created
May, B  (2011-02-05)