STIM1 oligomerizes

Stable Identifier
R-HSA-1168376
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen, cytosol
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STIM1 oligomerizes
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In the resting state the luminal domain of STIM1 binds Ca2+ ions within the endoplasmic reticulum and this binding prevents dimerization of STIM1 (Luik et al. 2008). Upon depletion of Ca2+ ions from the endoplasmic reticulum, STIM1 is no longer bound to Ca2+ and forms homodimers (Muik et al. 2008, Luik et al. 2008, Park et al. 2009).

Literature References
PubMed ID Title Journal Year
19249086 STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

Park, CY, Hoover, PJ, Mullins, FM, Bachhawat, P, Covington, ED, Raunser, S, Walz, T, Garcia, KC, Dolmetsch, RE, Lewis, RS

Cell 2009
18187424 Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation

Muik, M, Frischauf, I, Derler, I, Fahrner, M, Bergsmann, J, Eder, P, Schindl, R, Hesch, C, Polzinger, B, Fritsch, R, Kahr, H, Madl, J, Gruber, H, Groschner, K, Romanin, C

J Biol Chem 2008
18596693 Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

Luik, RM, Wang, B, Prakriya, M, Wu, MM, Lewis, RS

Nature 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cation channel activity of ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
Physical Entity
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
Activity
cation channel activity (0005261)
Orthologous Events
STIM1 oligomerizes (Caenorhabditis elegans)
STIM1 oligomerizes (Canis familiaris)
STIM1 oligomerizes (Danio rerio)
STIM1 oligomerizes (Drosophila melanogaster)
STIM1 oligomerizes (Gallus gallus)
STIM1 oligomerizes (Mus musculus)
STIM1 oligomerizes (Rattus norvegicus)
STIM1 oligomerizes (Sus scrofa)
STIM1 oligomerizes (Xenopus tropicalis)
Authored
May, B  (2011-01-19)
Reviewed
Wienands, J  (2012-02-12)
Created
May, B  (2010-12-19)