Reactome | STIM1 oligomerizes

STIM1 oligomerizes

Stable Identifier

R-HSA-1168376

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen, cytosol

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In the resting state the luminal domain of STIM1 binds Ca2+ ions within the endoplasmic reticulum and this binding prevents dimerization of STIM1 (Luik et al. 2008). Upon depletion of Ca2+ ions from the endoplasmic reticulum, STIM1 is no longer bound to Ca2+ and forms homodimers (Muik et al. 2008, Luik et al. 2008, Park et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19249086	STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1 Park, CY, Hoover, PJ, Mullins, FM, Bachhawat, P, Covington, ED, Raunser, S, Walz, T, Garcia, KC, Dolmetsch, RE, Lewis, RS	Cell	2009
18187424	Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation Muik, M, Frischauf, I, Derler, I, Fahrner, M, Bergsmann, J, Eder, P, Schindl, R, Hesch, C, Polzinger, B, Fritsch, R, Kahr, H, Madl, J, Gruber, H, Groschner, K, Romanin, C	J Biol Chem	2008
18596693	Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation Luik, RM, Wang, B, Prakriya, M, Wu, MM, Lewis, RS	Nature	2008