STIM1 oligomerizes

Stable Identifier
R-HSA-1168376
Type
Reaction
Species
Homo sapiens
Compartment
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In the resting state the luminal domain of STIM1 binds Ca2+ ions within the endoplasmic reticulum and this binding prevents dimerization of STIM1 (Luik et al. 2008). Upon depletion of Ca2+ ions from the endoplasmic reticulum, STIM1 is no longer bound to Ca2+ and forms homodimers (Muik et al. 2008, Luik et al. 2008, Park et al. 2009).

Literature References
PubMed ID Title Journal Year
18187424 Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation

Gruber, H, Frischauf, I, Romanin, C, Derler, I, Fahrner, M, Madl, J, Schindl, R, Eder, P, Polzinger, B, Hesch, C, Kahr, H, Muik, M, Fritsch, R, Bergsmann, J, Groschner, K

J Biol Chem 2008
19249086 STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

Bachhawat, P, Dolmetsch, RE, Hoover, PJ, Raunser, S, Park, CY, Covington, ED, Garcia, KC, Lewis, RS, Mullins, FM, Walz, T

Cell 2009
18596693 Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

Prakriya, M, Wu, MM, Wang, B, Lewis, RS, Luik, RM

Nature 2008
Participants
Participates
Catalyst Activity

cation channel activity of ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]

Orthologous Events
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