Fyn/Lyn-mediated phosphorylation of FcR1 gamma

Stable Identifier
R-HSA-114600
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Fyn/Lyn-mediated phosphorylation of FcR1 gamma
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'GP VI:Fc Epsilon R1 gamma:Collagen IV complex', and 1 molecule of 'ATP' are present. At the end of this reaction, 1 molecule of 'ADP', and 1 molecule of 'GP VI:phosphorylated Fc Epsilon R1 gamma:Collagen IV complex' are present.

This reaction is mediated by the 'protein-tyrosine kinase activity' of 'GP VI: Fc Epsilon R1 gamma: Collagen IV: SRC'.

Literature References
PubMed ID Title Journal Year
9028946 A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1

Asselin, J, Gibbins, JM, Achison, M, Lee, YH, Morton, LF, Farndale, RW, Barnes, MJ, Watson, SP

Blood 1997
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane]
Physical Entity
GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Bos taurus)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Mus musculus)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Rattus norvegicus)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Sus scrofa)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Xenopus tropicalis)
Created
de Bono, B  (2004-09-25)
Pace, NP  (2004-09-25)
Farndale, R  (2004-09-25)