Fyn/Lyn-mediated phosphorylation of FcR1 gamma

Stable Identifier
R-HSA-114600
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Fyn/Lyn-mediated phosphorylation of FcR1 gamma
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'GP VI:Fc Epsilon R1 gamma:Collagen IV complex', and 1 molecule of 'ATP' are present. At the end of this reaction, 1 molecule of 'ADP', and 1 molecule of 'GP VI:phosphorylated Fc Epsilon R1 gamma:Collagen IV complex' are present.

This reaction is mediated by the 'protein-tyrosine kinase activity' of 'GP VI: Fc Epsilon R1 gamma: Collagen IV: SRC'.
Literature References
PubMed ID Title Journal Year
9028946 A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1

Farndale, RW, Morton, LF, Watson, SP, Barnes, MJ, Gibbins, JM, Asselin, J, Lee, YH, Achison, M

Blood 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane]

Physical Entity
GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Bos taurus)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Canis familiaris)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Mus musculus)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Rattus norvegicus)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Sus scrofa)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Xenopus tropicalis)
Created
Farndale, R  (2004-09-25)
Pace, NP  (2004-09-25)
de Bono, B  (2004-09-25)
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