RAC1,RAC2,RHOG activate PI3K

Stable Identifier
R-HSA-114542
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PIP3 produced by PI3K activity is essential for receptor-driven stimulation of Rac activation, but PI3K also lies downstream of Rac, as Rac1 can form a complex with PI3K alpha leading to its activation.

Literature References
PubMed ID Title Journal Year
8645157 Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

Bokoch, GM, Vlahos, CJ, Wang, Y, Knaus, UG, Traynor-Kaplan, AE

Biochem J 1996
11803464 Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB

Murga, C, Zohar, M, Teramoto, H, Gutkind, JS

Oncogene 2002
7744773 Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation

Kovacsovics, TJ, Bachelot, C, Toker, A, Vlahos, CJ, Duckworth, B, Cantley, LC, Hartwig, JH

J Biol Chem 1995
Participants
Participant Of
Orthologous Events
Created