Reactome | RAC1,RAC2,RHOG activate PI3K

RAC1,RAC2,RHOG activate PI3K

Stable Identifier

R-HSA-114542

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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PIP3 produced by PI3K activity is essential for receptor-driven stimulation of Rac activation, but PI3K also lies downstream of Rac, as Rac1 can form a complex with PI3K alpha leading to its activation.

Literature References

PubMed ID	Title	Journal	Year
8645157	Rac GTPase interacts specifically with phosphatidylinositol 3-kinase Bokoch, GM, Vlahos, CJ, Wang, Y, Knaus, UG, Traynor-Kaplan, AE	Biochem J	1996
11803464	Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB Murga, C, Zohar, M, Teramoto, H, Gutkind, JS	Oncogene	2002
7744773	Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation Kovacsovics, TJ, Bachelot, C, Toker, A, Vlahos, CJ, Duckworth, B, Cantley, LC, Hartwig, JH	J Biol Chem	1995