RAC1,RAC2,RHOG activate PI3K

Stable Identifier
R-HSA-114542
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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RAC1,RAC2,RHOG activate PI3K
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PIP3 produced by PI3K activity is essential for receptor-driven stimulation of Rac activation, but PI3K also lies downstream of Rac, as Rac1 can form a complex with PI3K alpha leading to its activation.

Literature References
PubMed ID Title Journal Year
11803464 Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB

Murga, C, Teramoto, H, Zohar, M, Gutkind, JS

Oncogene 2002
8645157 Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

Knaus, UG, Wang, Y, Bokoch, GM, Traynor-Kaplan, AE, Vlahos, CJ

Biochem J 1996
7744773 Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation

Hartwig, JH, Cantley, LC, Toker, A, Bachelot, C, Duckworth, B, Vlahos, CJ, Kovacsovics, TJ

J Biol Chem 1995
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Orthologous Events
RAC1,RAC2,RHOG activate PI3K (Canis familiaris)
RAC1,RAC2,RHOG activate PI3K (Danio rerio)
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RAC1,RAC2,RHOG activate PI3K (Mus musculus)
RAC1,RAC2,RHOG activate PI3K (Rattus norvegicus)
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RAC1,RAC2,RHOG activate PI3K (Xenopus tropicalis)
Created
Farndale, R  (2004-09-25)
Pace, NP  (2004-09-25)
de Bono, B  (2004-09-25)
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