PIP3 produced by PI3K activity is essential for receptor-driven stimulation of Rac activation, but PI3K also lies downstream of Rac, as Rac1 can form a complex with PI3K alpha leading to its activation.
Bokoch, GM, Vlahos, CJ, Wang, Y, Knaus, UG, Traynor-Kaplan, AE
Murga, C, Zohar, M, Teramoto, H, Gutkind, JS
Kovacsovics, TJ, Bachelot, C, Toker, A, Vlahos, CJ, Duckworth, B, Cantley, LC, Hartwig, JH
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