Abortive termination of early transcription elongation by DSIF:NELF

Stable Identifier
R-HSA-113409
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the early elongation phase, shorter transcripts typically of ~30 nt in length are generated due to random termination of elongating nascent transcripts. This abortive cessation of elongation has been observed mainly in the presence of DSIF-NELF bound to Pol II complex. (Reviewed in Conaway et al.,2000; Shilatifard et al., 2003 ).

Literature References
PubMed ID Title Journal Year
12676794 The RNA polymerase II elongation complex.

Shilatifard, A, Conaway, RC, Conaway, JW

Annu Rev Biochem 2003
Participants
Participant Of
Orthologous Events
Authored
Created
Cite Us!