DSIF complex binds to RNA Pol II (hypophosphorylated)

Stable Identifier
R-HSA-113407
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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DSIF complex binds to RNA Pol II (hypophosphorylated)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
DSIF is a heterodimer consisting of hSPT4 (human homolog of yeast Spt4- p14) and hSPT5 (human homolog of yeast Spt5-p160). DSIF association with Pol II may be enabled by Spt5 binding to Pol II creating a scaffold for NELF binding (Wada et al.,1998). Spt5 subunit of DSIF can be phosphorylated by P-TEFb.
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Orthologous Events
DSIF complex binds to RNA Pol II (hypophosphorylated) (Bos taurus)
DSIF complex binds to RNA Pol II (hypophosphorylated) (Caenorhabditis elegans)
DSIF complex binds to RNA Pol II (hypophosphorylated) (Canis familiaris)
DSIF complex binds to RNA Pol II (hypophosphorylated) (Dictyostelium discoideum)
DSIF complex binds to RNA Pol II (hypophosphorylated) (Drosophila melanogaster)
DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)
DSIF complex binds to RNA Pol II (hypophosphorylated) (Mus musculus)
DSIF complex binds to RNA Pol II (hypophosphorylated) (Plasmodium falciparum)
DSIF complex binds to RNA Pol II (hypophosphorylated) (Rattus norvegicus)
DSIF complex binds to RNA Pol II (hypophosphorylated) (Saccharomyces cerevisiae)
DSIF complex binds to RNA Pol II (hypophosphorylated) (Schizosaccharomyces pombe)
DSIF complex binds to RNA Pol II (hypophosphorylated) (Sus scrofa)
Authored
Gopinathrao, G  (2004-05-03)
Created
Conaway, JW  (2003-09-11)
Conaway, RC  (2003-09-11)
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