Formation of DSIF:NELF:early elongation complex

Stable Identifier
R-HSA-113402
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Formation of DSIF:NELF:early elongation complex
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NELF complex is a ~ 300 kDa multiprotein complex composed of 5 peptides (A - E): ~66,61,59,58 and 46 kDa. All these peptides are required for NELF-mediated inhibition of Pol II elongation. NELF complex has been reported to bind to the pre-formed DSIF:RNA Pol II complex that may act as a scaffold for its binding. NELF-A is suspected to be involved in Wolf-Hirschhorn syndrome.
Binding of DSIF:NELF to RNA Pol II CTD results in abortive termination of early elongation steps by the growing transcripts.
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Orthologous Events
Formation of DSIF:NELF:early elongation complex (Bos taurus)
Formation of DSIF:NELF:early elongation complex (Canis familiaris)
Formation of DSIF:NELF:early elongation complex (Drosophila melanogaster)
Formation of DSIF:NELF:early elongation complex (Gallus gallus)
Formation of DSIF:NELF:early elongation complex (Mus musculus)
Formation of DSIF:NELF:early elongation complex (Rattus norvegicus)
Formation of DSIF:NELF:early elongation complex (Sus scrofa)
Formation of DSIF:NELF:early elongation complex (Xenopus tropicalis)
Formation of DSIF:NELF:HIV-1 early elongation complex (Homo sapiens)
Authored
Gopinathrao, G  (2004-06-22)
Created
Conaway, JW  (2003-09-11)
Conaway, RC  (2003-09-11)
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