Reactome | Formation of Elongin BC complex

Formation of Elongin BC complex

Stable Identifier

R-HSA-112435

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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At the beginning of this reaction, 1 molecule of 'Elongin B protein', and 1 molecule of 'Elongin C protein' are present. At the end of this reaction, 1 molecule of 'Elongin B:C complex' is present. This reaction takes place in the 'nucleus' (Aso et al., 1995; Duan et al., 1995b; Kibel et al., 1995).

Literature References

PubMed ID	Title	Journal	Year
7660122	Inhibition of transcription elongation by the VHL tumor suppressor protein Duan, DR, Pause, A, Burgess, WH, Aso, T, Chen, DY, Garrett, KP, Conaway, RC, Conaway, JW, Linehan, WM, Klausner, RD	Science	1995
7660129	Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II Aso, T, Lane, WS, Conaway, JW, Conaway, RC	Science	1995
7660130	Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C Kibel, A, Iliopoulos, O, DeCaprio, JA, Kaelin, WG	Science	1995