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Resumption of elongation after recovery from pausing
Stable Identifier
R-HSA-112392
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
Resumption of elongation after recovery from pausing (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Recovery from pausing occurs spontaneously after a variable length of time as the enzyme spontaneously slides forward again. This renders the transcript's 3'-OH terminus realigned with the catalytic Mg2+ site of the enzyme. TFIIS is capable of excising the nascent transcript at 2 or 3 nucleotides upstream of the transcript's 3'-end to reinitiate processive elongation (reviewed by Shilatifard et al., 2003).
Literature References
PubMed ID
Title
Journal
Year
12676794
The RNA polymerase II elongation complex.
Conaway, JW
,
Shilatifard, A
,
Conaway, RC
Annu Rev Biochem
2003
Participants
Input
Paused processive elongation complex [nucleoplasm]
(Homo sapiens)
Output
Processive elongation complex [nucleoplasm]
(Homo sapiens)
Participates
as an event of
RNA Polymerase II Pre-transcription Events (Homo sapiens)
Orthologous Events
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Resumption of elongation after recovery from pausing (Drosophila melanogaster)
Resumption of elongation after recovery from pausing (Gallus gallus)
Resumption of elongation after recovery from pausing (Mus musculus)
Resumption of elongation after recovery from pausing (Rattus norvegicus)
Resumption of elongation after recovery from pausing (Sus scrofa)
Resumption of elongation after recovery from pausing (Xenopus tropicalis)
Authored
Gopinathrao, G (2004-06-23)
Created
Conaway, JW (2003-09-11)
Conaway, RC (2003-09-11)
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