Reactome | Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor

Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor

Stable Identifier

R-HSA-1112602

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor

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Interleukin-6 (IL6) activates the tyrosine phosphorylation of STATs (Akira et al. 1994, Zhong et al. 1994) by receptor-associated JAKs (Hemmann et al. 1996) at a site that is essential for dimerization. For STAT1 this is tyrosine-701, for STAT3 tyrosine-705 (Kaptein et al. 1996, Shuai et al. 1994). Tyrosine phosphorylation leads to homo- or heterodimerization and translocation to the nucleus (Zhong et al. 1994), where the dimers bind to enhancers of IL6- inducible genes e.g. acute phase protein genes, resulting in transcriptional activation.

Literature References

PubMed ID	Title	Journal	Year
8662795	Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation Heinrich, PC, Sasse, J, Horn, F, Darnell JE, Jr, Zhong, Z, Graeve, L, Hemmann, U, Wollmer, A, Kurapkat, G, Heesel, B, Grötzinger, J, Gerhartz, C	J Biol Chem	1996