STAT1 and STAT3 dimers translocate to the nucleus

Stable Identifier
R-HSA-1112587
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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STAT1 and STAT3 dimers translocate to the nucleus
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In untreated cells STAT1 and STAT3 are distributed diffusely in the cytoplasm and nucleus. A few minutes after Interleukin-6 treatment both are preferentially located in the nucleus. This translocation is transient; after 2 hours the distribution is comparable to that of untreated cells (Zhang et al. 1995). It is believed that STATs entry to the nucleus is mediated by importins via nuclear pore complexes (NPCs) (Reich & Liu 2006).
Literature References
PubMed ID Title Journal Year
7701321 Requirement of serine phosphorylation for formation of STAT-promoter complexes

Chen-Kiang, S, Li, HC, Zhang, X, Blenis, J, Schindler, C

Science 1995
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Authored
Ray, KP  (2010-12-13)
Reviewed
Rose-John, S  (2011-02-11)
Created
Jupe, S  (2010-12-03)
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