Reactome | STAT1 and STAT3 dimers translocate to the nucleus

STAT1 and STAT3 dimers translocate to the nucleus

Stable Identifier

R-HSA-1112587

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

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STAT1 and STAT3 dimers translocate to the nucleus

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In untreated cells STAT1 and STAT3 are distributed diffusely in the cytoplasm and nucleus. A few minutes after Interleukin-6 treatment both are preferentially located in the nucleus. This translocation is transient; after 2 hours the distribution is comparable to that of untreated cells (Zhang et al. 1995). It is believed that STATs entry to the nucleus is mediated by importins via nuclear pore complexes (NPCs) (Reich & Liu 2006).

Literature References

PubMed ID	Title	Journal	Year
7701321	Requirement of serine phosphorylation for formation of STAT-promoter complexes Zhang, X, Blenis, J, Li, HC, Schindler, C, Chen-Kiang, S	Science	1995