Binding of Grb10 to the insulin receptor

Stable Identifier
R-HSA-110011
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Binding of Grb10 to the insulin receptor
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Grb10 negatively regulates the insulin-dependent phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor (Wick et al, 2003;Langlais et al, 2004).
Literature References
PubMed ID Title Journal Year
12493740 Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.

Wick, KR, Werner, ED, Langlais, P, Ramos, FJ, Dong, LQ, Shoelson, SE, Liu, F

J Biol Chem 2003
14615605 Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10.

Langlais, P, Dong, LQ, Ramos, FJ, Hu, D, Li, Y, Quon, MJ, Liu, F

Mol Endocrinol 2004
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Orthologous Events
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Created
Charalambous, M  (2004-04-29)
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