Reactome | PDPK1 binds PIP3

PDPK1 binds PIP3

Stable Identifier

R-HSA-109701

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        PDPK1 binds PIP3 (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        PDPK1 binds PIP3 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PIP3 generated by PI3K recruits phosphatidylinositide-dependent protein kinase 1 (PDPK1 i.e. PDK1) to the membrane, through its PH (pleckstrin-homology) domain. PDPK1 binds PIP3 with high affinity, and also shows low affinity for PIP2 (Currie et al. 1999; Anderson et al, 1998).

Literature References

PubMed ID	Title	Journal	Year
9895304	Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 Currie, RA, Walker, KS, Gray, A, Deak, M, Casamayor, A, Downes, CP, Cohen, P, Alessi, DR, Lucocq, J	Biochem J	1999
9637919	Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B Anderson, KE, Coadwell, J, Stephens, LR, Hawkins, PT	Curr. Biol.	1998