Reactome | PDPK1 binds PIP3

PDPK1 binds PIP3

Stable Identifier

R-HSA-109701

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        PDPK1 binds PIP3 (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        PDPK1 binds PIP3 (Homo sapiens)

General

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PIP3 generated by PI3K recruits phosphatidylinositide-dependent protein kinase 1 (PDPK1 i.e. PDK1) to the membrane, through its PH (pleckstrin-homology) domain. PDPK1 binds PIP3 with high affinity, and also shows low affinity for PIP2 (Currie et al. 1999; Anderson et al, 1998).

Literature References

PubMed ID	Title	Journal	Year
9895304	Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 Alessi, DR, Cohen, P, Downes, CP, Casamayor, A, Lucocq, J, Currie, RA, Deak, M, Gray, A, Walker, KS	Biochem J	1999
9637919	Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B Coadwell, J, Hawkins, PT, Stephens, LR, Anderson, KE	Curr. Biol.	1998