PDPK1 binds PIP3

Stable Identifier
Reaction [binding]
Homo sapiens
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PIP3 generated by PI3K recruits phosphatidylinositide-dependent protein kinase 1 (PDPK1 i.e. PDK1) to the membrane, through its PH (pleckstrin-homology) domain. PDPK1 binds PIP3 with high affinity, and also shows low affinity for PIP2 (Currie et al. 1999; Anderson et al, 1998).

Literature References
PubMed ID Title Journal Year
9637919 Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

Anderson, KE, Coadwell, J, Stephens, LR, Hawkins, PT

Curr. Biol. 1998
9895304 Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

Currie, RA, Walker, KS, Gray, A, Deak, M, Casamayor, A, Downes, CP, Cohen, P, Alessi, DR, Lucocq, J

Biochem J 1999
Participant Of
Orthologous Events
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