Soluble IL6ST (sgp130) binds to circulating Interleukin-6 (IL6) bound to the soluble form of IL6 receptor alpha (IL6:IL6R-2), preventing binding to IL6ST (gp130) on the plasma membrane, thereby specifically inhibiting IL6 trans-signaling (Jostock et al. 2001).
Voltz, N, Blinn, G, Neurath, MF, Fischer, M, Atreya, R, Jostock, T, Rose-John, S, Ozbek, S, Müllberg, J
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