IL6:IL6R-2 binds IL6ST-2

Stable Identifier
R-HSA-1067676
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
IL6:sIL6R binds sgp130
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IL6:IL6R-2 binds IL6ST-2
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Soluble IL6ST (sgp130) binds to circulating Interleukin-6 (IL6) bound to the soluble form of IL6 receptor alpha (IL6:IL6R-2), preventing binding to IL6ST (gp130) on the plasma membrane, thereby specifically inhibiting IL6 trans-signaling (Jostock et al. 2001).

Literature References
PubMed ID Title Journal Year
11121117 Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

Jostock, T, Müllberg, J, Ozbek, S, Atreya, R, Blinn, G, Voltz, N, Fischer, M, Neurath, MF, Rose-John, S

Eur J Biochem 2001
Participants
Input
Output
Participant Of
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Orthologous Events
IL6:IL6R-2 binds IL6ST-2 (Bos taurus)
IL6:IL6R-2 binds IL6ST-2 (Danio rerio)
IL6:IL6R-2 binds IL6ST-2 (Gallus gallus)
IL6:IL6R-2 binds IL6ST-2 (Mus musculus)
IL6:IL6R-2 binds IL6ST-2 (Rattus norvegicus)
IL6:IL6R-2 binds IL6ST-2 (Xenopus tropicalis)
Authored
Ray, KP  (2010-12-13)
Reviewed
Rose-John, S  (2011-02-11)
Created
Jupe, S  (2010-11-26)
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