IL6:IL6R-2 binds IL6ST-2

Stable Identifier
R-HSA-1067676
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
IL6:sIL6R binds sgp130
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Soluble IL6ST (sgp130) binds to circulating Interleukin-6 (IL6) bound to the soluble form of IL6 receptor alpha (IL6:IL6R-2), preventing binding to IL6ST (gp130) on the plasma membrane, thereby specifically inhibiting IL6 trans-signaling (Jostock et al. 2001).

Literature References
PubMed ID Title Journal Year
11121117 Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

Jostock, T, Müllberg, J, Ozbek, S, Atreya, R, Blinn, G, Voltz, N, Fischer, M, Neurath, MF, Rose-John, S

Eur J Biochem 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created