Soluble IL6ST (sgp130) binds to circulating Interleukin-6 (IL6) bound to the soluble form of IL6 receptor alpha (IL6:IL6R-2), preventing binding to IL6ST (gp130) on the plasma membrane, thereby specifically inhibiting IL6 trans-signaling (Jostock et al. 2001).
Jostock, T, Müllberg, J, Ozbek, S, Atreya, R, Blinn, G, Voltz, N, Fischer, M, Neurath, MF, Rose-John, S
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