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DOCK4 [cytosol]
Stable Identifier
R-HSA-1012995
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Dedicator of cytokinesis protein 4, DOCK4_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
DOCKs bind to RhoGEFs (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
DOCK4 [cytosol] (Homo sapiens)
DOCK-GEFs:RAC1, CDC42 [cytosol] (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
DOCK4 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
DOCK4 [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 GEFs activate RAC2 (Homo sapiens)
RAC2 GEFs [cytosol] (Homo sapiens)
DOCK4 [cytosol] (Homo sapiens)
RHOG GTPase cycle (Homo sapiens)
RHOG binds effectors at the plasma membrane (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
DOCK4 [cytosol] (Homo sapiens)
RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
DOCK4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N1I0 DOCK4
Gene Names
DOCK4, KIAA0716
Chain
chain:1-1966
Reference Genes
BioGPS Gene:9732 DOCK4
COSMIC (genes):DOCK4 DOCK4
CTD Gene:9732 DOCK4
dbSNP Gene:9732 DOCK4
ENSEMBL:ENSG00000128512 DOCK4
HGNC:19192 DOCK4
KEGG:hsa:9732 DOCK4
Monarch:9732 DOCK4
NCBI Gene:9732 DOCK4
OMIM:607679 DOCK4
UCSC:Q8N1I0 DOCK4
Reference Transcript
RefSeq:NM_014705.3 DOCK4
RefSeq:XM_006716189.2 DOCK4
RefSeq:XM_006716188.2 DOCK4
Other Identifiers
11726190_a_at
11747730_a_at
11751895_a_at
17061881
205003_PM_at
205003_at
241313_PM_at
241313_at
3068098
3068099
3068100
3068101
3068103
3068104
3068106
3068108
3068109
3068110
3068111
3068112
3068113
3068114
3068115
3068116
3068117
3068118
3068120
3068123
3068124
3068126
3068127
3068128
3068129
3068135
3068136
3068137
3068138
3068140
3068141
3068142
3068143
3068146
3068147
3068151
3068152
3068154
3068157
3068159
3068162
3068164
3068165
3068177
3068178
3068179
3068182
3068183
3068184
3068186
3068187
3068188
3068192
3068196
3068197
3068199
3068200
3068203
3068210
3068212
3068213
3068214
3068234
3068235
3068237
3068241
3068243
3068246
3068247
3068248
3068249
3068278
3068279
3068283
3068285
3068287
3068288
41620_at
65208_at
8142345
9732
A_23_P364580
A_23_P59637
A_24_P324886
GE53440
GE902414
GO:0003013
GO:0005085
GO:0005096
GO:0005515
GO:0005730
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0007264
GO:0016020
GO:0017124
GO:0030165
GO:0030971
GO:0031267
GO:0032420
GO:0032421
GO:0042995
GO:0043226
GO:0048870
GO:0060326
GO:0098772
GO:0098794
GO:0098978
GO:0150052
GO:1904694
GO:1904754
HMNXSV003029008
Hs.134714.0.A1_3p_at
ILMN_1801044
PH_hs_0006490
TC07001761.hg
g7662263_3p_at
Participates
as a candidate of
RAC2 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
as a member of
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
Inferred To
docA [cytosol]
(Dictyostelium discoideum)
Dock4 [cytosol]
(Mus musculus)
Dock4 [cytosol]
(Rattus norvegicus)
Homologues of DOCK4 [cytosol]
(Dictyostelium discoideum)
docB [cytosol]
(Dictyostelium discoideum)
docD [cytosol]
(Dictyostelium discoideum)
dock4 [cytosol]
(Xenopus tropicalis)
spg [cytosol]
(Drosophila melanogaster)
docC [cytosol]
(Dictyostelium discoideum)
DOCK4 [cytosol]
(Bos taurus)
DOCK4 [cytosol]
(Canis familiaris)
DOCK4 [cytosol]
(Gallus gallus)
DOCK4 [cytosol]
(Sus scrofa)
DCK1 [cytosol]
(Saccharomyces cerevisiae)
Cross References
ENSEMBL
ENST00000437633
,
ENST00000428084
,
ENSG00000128512
,
ENSP00000410746
,
ENSP00000404179
OpenTargets
ENSG00000128512
GeneCards
DOCK4
HPA
ENSG00000128512-DOCK4
PRO
Q8N1I0
Pharos - Targets
Q8N1I0
GlyGen
Q8N1I0
HMDB Protein
HMDBP08355
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.738
5
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