CD46 binds C3b

Stable Identifier
R-HSA-1006143
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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CD46 binds C3b
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Membrane cofactor protein (MCP; CD46) is a widely distributed C3b/C4b-binding cell surface glycoprotein which is a cofactor for Complement factor I.

Literature References
PubMed ID Title Journal Year
2481448 Functional properties of membrane cofactor protein of complement

Seya, T, Atkinson, JP

Biochem J 1989
12055245 Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells

Barilla-LaBarca, ML, Liszewski, MK, Lambris, JD, Hourcade, D, Atkinson, JP

J Immunol 2002
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Orthologous Events
CD46 binds C3b (Caenorhabditis elegans)
CD46 binds C3b (Canis familiaris)
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CD46 binds C3b (Drosophila melanogaster)
CD46 binds C3b (Gallus gallus)
CD46 binds C3b (Mus musculus)
CD46 binds C3b (Rattus norvegicus)
CD46 binds C3b (Sus scrofa)
Authored
Jupe, S  (2010-11-09)
Reviewed
Bradley, DT  (2012-02-13)
Fraczek, LA  (2012-02-13)
Created
Jupe, S  (2010-11-10)
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