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p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane]
Stable Identifier
R-GGA-993983
Type
Complex
Species
Gallus gallus
Compartment
endosome membrane
Locations in the PathwayBrowser
Expand all
Innate Immune System (Gallus gallus)
Toll-like receptors (TLR) cascades (Gallus gallus)
TLR21 cascade (Gallus gallus)
MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
Activated TAK1 leaves endosome membrane (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
TLR7 cascade (Gallus gallus)
MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
Activated TAK1 leaves endosome membrane (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
Participants
components
x 2
chicken TAB2/TAB3 [endosome membrane]
(Gallus gallus)
x 2
free K63_polyubiquitin chain [cytosol]
(Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane]
(Gallus gallus)
x 2
phosphorylated TAK1 [endosome membrane]
(Gallus gallus)
x 2
TAB1 [endosome membrane]
(Gallus gallus)
Participates
as an output of
Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)
as an input of
Activated TAK1 leaves endosome membrane (Gallus gallus)
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