Reactome | ASB5 [cytosol]

ASB5 [cytosol]

Stable Identifier

R-GGA-975420

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

ASB5, E1C918

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Adaptive Immune System (Gallus gallus)
  - Class I MHC mediated antigen processing & presentation (Gallus gallus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
      - Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Gallus gallus)
        
        ASB family [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Gallus gallus)
        
        ASB family [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
      - Polyubiquitination of substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Gallus gallus)
        
        ASB family [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Gallus gallus)
        
        ASB family [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Gallus gallus)
        
        ASB family [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
      - Release of E3 from polyubiquitinated substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Gallus gallus)
        
        ASB family [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Gallus gallus)
        
        ASB family [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
      - Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Gallus gallus)
        
        ASB family [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Gallus gallus)
        
        ASB family [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Gallus gallus)
        
        ASB family [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)

Metabolism of proteins (Gallus gallus)

- Post-translational protein modification (Gallus gallus)
  - Neddylation (Gallus gallus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Gallus gallus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        CUL5-box protein [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Gallus gallus)
        
        CUL5-box protein [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Gallus gallus)
        
        CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        CUL5-box protein [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
      - CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        CUL5-box protein [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Gallus gallus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        CUL5-box protein [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Gallus gallus)
        
        CUL5-box protein [cytosol] (Gallus gallus)
        
        ASB5 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:E1C918

Gene Names

ASB5

Reference Genes

BioGPS Gene:422572 ASB5

ENSEMBL:ENSGALG00000010837

ENSEMBL:ENSGALG00010003412.1 ASB5

Monarch:422572 ASB5

NCBI Gene:422572 ASB5

Reference Transcript

Other Identifiers

422572

GO:0005515

GO:0016567

GO:0023052

GO:0030163

GO:0035556

GO:0036211

GO:0045732

Gga.10870.1.S1_a_at

Participates

as a member of

Inferred From

ASB5 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015132014.1, XP_015132017.1, XP_015132016.1, XP_015132015.1, XP_015132018.1

OpenTargets

ENSG00000164122

Ensembl

ENSGALP00010004766, ENSGALT00010007940, ENSGALG00010003412

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