Reactome | phospho-Autophosphorylated FLT3 [plasma membrane]

phospho-Autophosphorylated FLT3 [plasma membrane]

Stable Identifier

R-GGA-9604780

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

A0A8V0XQ80

Locations in the PathwayBrowser

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Signal Transduction (Gallus gallus)

- Intracellular signaling by second messengers (Gallus gallus)
  - PIP3 activates AKT signaling (Gallus gallus)
    - Negative regulation of the PI3K/AKT network (Gallus gallus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
        
        PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
        
        Activator:PI3K [plasma membrane] (Gallus gallus)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Gallus gallus)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Gallus gallus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Gallus gallus)
        
        Active FLT3: GRB2 [plasma membrane] (Gallus gallus)
        
        Active FLT3 [plasma membrane] (Gallus gallus)
        
        phospho-Autophosphorylated FLT3 [plasma membrane] (Gallus gallus)
    - PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
      - Activator:PI3K [plasma membrane] (Gallus gallus)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Gallus gallus)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Gallus gallus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Gallus gallus)
        
        Active FLT3: GRB2 [plasma membrane] (Gallus gallus)
        
        Active FLT3 [plasma membrane] (Gallus gallus)
        
        phospho-Autophosphorylated FLT3 [plasma membrane] (Gallus gallus)
- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
        
        RAS GEFs [plasma membrane] (Gallus gallus)
        
        Active FLT3:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        Active FLT3: GRB2 [plasma membrane] (Gallus gallus)
        
        Active FLT3 [plasma membrane] (Gallus gallus)
        
        phospho-Autophosphorylated FLT3 [plasma membrane] (Gallus gallus)
- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by Insulin receptor (Gallus gallus)
    - Insulin receptor signalling cascade (Gallus gallus)
      - IRS-mediated signalling (Gallus gallus)
        
        PI3K Cascade (Gallus gallus)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
        
        PI3K-containing complexes [cytosol] (Gallus gallus)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Gallus gallus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Gallus gallus)
        
        Active FLT3: GRB2 [plasma membrane] (Gallus gallus)
        
        Active FLT3 [plasma membrane] (Gallus gallus)
        
        phospho-Autophosphorylated FLT3 [plasma membrane] (Gallus gallus)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Gallus gallus)
    - IGF1R signaling cascade (Gallus gallus)
      - IRS-related events triggered by IGF1R (Gallus gallus)
        
        IRS-mediated signalling (Gallus gallus)
        
        PI3K Cascade (Gallus gallus)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
        
        PI3K-containing complexes [cytosol] (Gallus gallus)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Gallus gallus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Gallus gallus)
        
        Active FLT3: GRB2 [plasma membrane] (Gallus gallus)
        
        Active FLT3 [plasma membrane] (Gallus gallus)
        
        phospho-Autophosphorylated FLT3 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0XQ80

Reference Genes

BioGPS Gene:100858422

ENSEMBL:ENSGALG00010004758.1

KEGG:gga:100858422

Monarch:100858422

NCBI Gene:100858422

UCSC:A0A8V0XQ80

Reference Transcript

RefSeq:XM_003640612.6

Other Identifiers

100858422

GO:0000166

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0004888

GO:0005524

GO:0005783

GO:0005886

GO:0006468

GO:0007166

GO:0007169

GO:0008284

GO:0016020

GO:0016301

GO:0016477

GO:0016740

GO:0019221

GO:0019838

GO:0030097

GO:0030154

GO:0030183

GO:0043235

GO:0046872

GO:0048856

GO:0048870

GO:0140096

GT_A_87_P111268

GgaAffx.10948.1.S1_at

GgaAffx.10948.2.S1_s_at

GgaAffx.10948.3.S1_s_at

Participates

as a component of

Active FLT3 [plasma membrane] (Gallus gallus)

Other forms of this molecule

FLT3 [plasma membrane]

Inferred From

Autophosphorylated FLT3 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 589 (in Homo sapiens)

Coordinate

589

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 591 (in Homo sapiens)

Coordinate

591

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 599 (in Homo sapiens)

Coordinate

599

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 768 (in Homo sapiens)

Coordinate

768

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 955 (in Homo sapiens)

Coordinate

955

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 969 (in Homo sapiens)

Coordinate

969

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_003640660.3

ENSEMBL

ENSGALG00010004758, ENSGALT00010011073, ENSGALP00010006303

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