Reactome | SYT2 [clathrin-coated endocytic vesicle membrane]

SYT2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-GGA-8869116

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

SYT2, A0A8V1A869

Locations in the PathwayBrowser

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Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V1A869

Gene Names

SYT2

Reference Genes

ENSEMBL:ENSGALG00010026315.1

UCSC:A0A8V1A869 SYT2

Other Identifiers

396327

GO:0000149

GO:0005509

GO:0005544

GO:0005886

GO:0016020

GO:0016192

GO:0017158

GO:0030424

GO:0030672

GO:0031045

GO:0031410

GO:0042584

GO:0045202

GO:0046872

GO:0061891

GO:0070382

GO:0099502

GO:1903861

GO:2000300

Gga.765.1.S1_at

Participates

as a component of

SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

Other forms of this molecule

SYT2 [plasma membrane]

Inferred From

SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSGALT00010064046, ENSGALP00010039420, ENSGALG00010026315

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