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NBN [nucleoplasm]
Stable Identifier
R-GGA-75163
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
nucleoplasm
Synonyms
NBN, A0A8V0YA70
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular Senescence (Gallus gallus)
DNA Damage/Telomere Stress Induced Senescence (Gallus gallus)
KAT5 acetylates ATM at DNA DSBs (Gallus gallus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
KAT5 acetylates ATM at shortened telomeres (Gallus gallus)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Gallus gallus)
Shortened telomere:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Gallus gallus)
Shortened telomere:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
MRN activates ATM (Gallus gallus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
MRN bound to shortened telomeres activates ATM (Gallus gallus)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Gallus gallus)
Shortened telomere:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Gallus gallus)
Shortened telomere:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
MRN complex binds DNA double strand breaks (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
MRN complex binds shortened telomeres (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
Shortened telomere:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
MRN complex bound to DNA ends recruits ATM (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
MRN complex bound to shortened telomeres recruits ATM (Gallus gallus)
Shortened telomere:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Gallus gallus)
Shortened telomere:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
DNA Repair (Gallus gallus)
DNA Double-Strand Break Repair (Gallus gallus)
DNA Double Strand Break Response (Gallus gallus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Gallus gallus)
ATM phosphorylates NBN (Gallus gallus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
Sensing of DNA Double Strand Breaks (Gallus gallus)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
KAT5 acetylates ATM at DNA DSBs (Gallus gallus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
KPNA2 translocates NBN to the nucleus (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
MRN activates ATM (Gallus gallus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
MRN complex binds DNA double strand breaks (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
MRN complex bound to DNA ends recruits ATM (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
Homology Directed Repair (Gallus gallus)
HDR through MMEJ (alt-NHEJ) (Gallus gallus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
MRN and RBBP8 resect DNA DSBs in MMEJ (Gallus gallus)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Gallus gallus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
MRN complex binds RBBP8 (Gallus gallus)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
DNA DSBs:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Gallus gallus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Gallus gallus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Gallus gallus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Gallus gallus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Gallus gallus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Gallus gallus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Gallus gallus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Gallus gallus)
MRN [nucleoplasm] (Gallus gallus)
NBN [nucleoplasm] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0YA70
Gene Names
NBN
Reference Genes
BioGPS Gene:374246 NBN
ENSEMBL:ENSGALG00010012671.1
Monarch:374246 NBN
NCBI Gene:374246 NBN
UCSC:A0A8V0YA70 NBN
Reference Transcript
RefSeq:XM_015282762.4 NBN
Other Identifiers
374246
GO:0000077
GO:0000723
GO:0000724
GO:0000729
GO:0000781
GO:0002376
GO:0003677
GO:0003684
GO:0005515
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005730
GO:0005794
GO:0006281
GO:0006302
GO:0006310
GO:0006974
GO:0007093
GO:0007095
GO:0007405
GO:0016605
GO:0022414
GO:0030870
GO:0031848
GO:0031860
GO:0032200
GO:0032206
GO:0035861
GO:0042393
GO:0042405
GO:0043247
GO:0043539
GO:0045190
GO:0050877
GO:0050885
GO:0051321
GO:0060090
GO:0062176
GO:0070533
GO:0090656
GO:0090737
GO:0097193
GO:0097681
GO:0098772
GO:0110025
GO:0140031
GO:0140297
GO:0140463
GO:1904354
GO:1990166
GO:2000781
Gga.196.1.S1_at
Participates
as an input of
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Gallus gallus)
as a component of
MRN [nucleoplasm] (Gallus gallus)
as an output of
KPNA2 translocates NBN to the nucleus (Gallus gallus)
Other forms of this molecule
NBN [cytosol]
phospho-NBN [nucleoplasm]
Inferred From
NBN [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_015138248.2
ENSEMBL
ENSGALG00010012671
,
ENSGALT00010030381
,
ENSGALP00010017623
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