Reactome | RPS12 [cytosol]

RPS12 [cytosol]

Stable Identifier

R-GGA-72329

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

RPS12, P84175

Locations in the PathwayBrowser

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Metabolism of RNA (Gallus gallus)

- Nonsense-Mediated Decay (NMD) (Gallus gallus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Gallus gallus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Gallus gallus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        40S ribosomal complex [cytosol] (Gallus gallus)
        
        RPS12 [cytosol] (Gallus gallus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        40S ribosomal complex [cytosol] (Gallus gallus)
        
        RPS12 [cytosol] (Gallus gallus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Gallus gallus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        40S ribosomal complex [cytosol] (Gallus gallus)
        
        RPS12 [cytosol] (Gallus gallus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Gallus gallus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Gallus gallus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        40S ribosomal complex [cytosol] (Gallus gallus)
        
        RPS12 [cytosol] (Gallus gallus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        40S ribosomal complex [cytosol] (Gallus gallus)
        
        RPS12 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:P84175

Gene Names

RPS12

Reference Genes

BioGPS Gene:421698 RPS12

ENSEMBL:ENSGALG00010004255

Monarch:421698 RPS12

NCBI Gene:421698 RPS12

UCSC:P84175 RPS12

Reference Transcript

Other Identifiers

421698

GO:0003735

GO:0005198

GO:0005794

GO:0005829

GO:0005840

GO:0006412

GO:0022626

GO:0022627

GO:0032040

GO:0042274

GO:0090263

GT_A_87_P099036

GT_A_87_P259358

GT_Xhyb_Chicken_CO763188_4649

Gga.4524.2.S1_a_at

Participates

as a component of

Inferred From

RPS12 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_046769949.1, XP_046769950.1, XP_040553069.1, XP_015139591.1

ENSEMBL

ENSGALT00010009962, ENSGALP00010005839, ENSGALG00010004255

PRO

P84175

PDB

8Q7Z, 8Q87

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