Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation

Stable Identifier
R-GGA-573296
Type
Reaction [binding]
Species
Gallus gallus
Compartment
cytosol, endosome membrane
ReviewStatus
5/5
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Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation
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Polyubiquitinated TRAF6 activates TAK1 by binding to the ubiquitin receptor TAB2 (also known as MAP3K7IP2). This binding leads to autophosphorylation and activation of TAK1.
Literature References
PubMed ID Title Journal Year
17496917 Ubiquitin-mediated activation of TAK1 and IKK

Adhikari, A, Xu, M, Chen, ZJ

Oncogene 2007
19675569 Direct activation of protein kinases by unanchored polyubiquitin chains

Xia, ZP, Sun, L, Chen, X, Pineda, G, Jiang, X, Adhikari, A, Zeng, W, Chen, ZJ

Nature 2009
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Inferred From
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Authored
Shamovsky, V  (2010-11-30)
Reviewed
D'Eustachio, P  (2010-12-06)
Created
Shamovsky, V  (2010-04-09)
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