Reactome | IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex

IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex

Stable Identifier

R-GGA-571327

Type

Reaction [transition]

Species

Gallus gallus

Compartment

endosome membrane, cytosol

ReviewStatus

5/5

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IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex

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In mammals activated IRAK4 phosphorylates both IRAK1 and IRAK2. Activated IRAK1 and IRAK2 in turn induce NFkB and AP-1 intracellular signaling cascades mediated by TRAF6.

Bioinformatic analysis reveals no evidence of IRAK1 in the chicken genome. It is possible that the chicken TLR pathway utilizes only IRAK-2, which shares 47% amino acid sequence identity with human IRAK2.

Literature References

PubMed ID	Title	Journal	Year
18438411	Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 Kawagoe, T, Sato, S, Matsushita, K, Kato, H, Matsui, K, Kumagai, Y, Saitoh, T, Kawai, T, Takeuchi, O, Akira, S	Nat Immunol	2008