IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex

Stable Identifier
R-GGA-571327
Type
Reaction [transition]
Species
Gallus gallus
Compartment
endosome membrane, cytosol
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IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex
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In mammals activated IRAK4 phosphorylates both IRAK1 and IRAK2. Activated IRAK1 and IRAK2 in turn induce NFkB and AP-1 intracellular signaling cascades mediated by TRAF6.

Bioinformatic analysis reveals no evidence of IRAK1 in the chicken genome. It is possible that the chicken TLR pathway utilizes only IRAK-2, which shares 47% amino acid sequence identity with human IRAK2.

Literature References
PubMed ID Title Journal Year
18438411 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2

Kawagoe, T, Sato, S, Matsushita, K, Kato, H, Matsui, K, Kumagai, Y, Saitoh, T, Kawai, T, Takeuchi, O, Akira, S

Nat Immunol 2008
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Catalyst Activity

protein serine/threonine kinase activity of IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane]

Physical Entity
IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] (Gallus gallus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
Authored
Shamovsky, V  (2010-11-30)
Reviewed
D'Eustachio, P  (2010-12-06)
Created
Shamovsky, V  (2010-04-09)
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