Reactome | Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex.

Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex.

Stable Identifier

R-GGA-571316

Type

Reaction [transition]

Species

Gallus gallus

Compartment

endosome membrane, cytosol

ReviewStatus

5/5

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Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex.

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Chicken IRAK4 shows 66% amino acid identity to human IRAK4. It is assumed here that chicken IRAK4 is activated by autophosphorylation like its human homologue.

Literature References

PubMed ID	Title	Journal	Year
18438411	Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 Kumagai, Y, Kawai, T, Takeuchi, O, Saitoh, T, Matsushita, K, Sato, S, Akira, S, Matsui, K, Kato, H, Kawagoe, T	Nat Immunol	2008
14625308	Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling Wesche, H, Li, S, Martin, MU, Knop, J, Neumann, D, Cao, P, Mackensen, AC, Kollewe, C	J Biol Chem	2004